Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"micro-environment"”.
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Engineering the micro-environment to control the fate of mammalian cells
… and bio-chemical factors in the local micro-environment like substrate stiffness, geometry, ligand density, and topography can have strong influences on determining the fate of cells. Mammalian cells respond to this myriad of micro-environmental cues by an interplay between actomyosin …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
… Reduces Immune Suppression in the Early Tumor Micro-Environment</p> <p>Brenda Melendez, B.S.</p> <p>Advisory Professor: Gregory Lizee, PhD.</p> <p>Immunotherapy against melanoma has shown great promise in the clinic for treating advanced-stage patients. However, a major barrier against …
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Mimicking the micro-environment. Construction and evaluation of complex collagen-based scaffolds for tissue engineering
Contains fulltext : 99159.pdf (Publisher’s version ) (Open Access)
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Control of flow and oxygen in a 3-D perfused micro-environment fosters balanced survival of hepatocyte-non-parenchymal cell co-cultures
… perfused system, and maintained for two weeks. Micro-flow rates of different media through the formed tissue units in scaffolds were controlled using pneumatic pumps and microfluidics. Staining and confocal imaging of endpoint tissue showed that lower flow rates closer to physiological regimes …
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The autecology of the adult horn fly, Haematobia irritans (L.), (Diptera: Muscidae) on dairy cattle
… conducted to correlate the effect of the macro-environment on the micro-environment within the ½ inch mantle of the animal, and also to correlate the locations of horn flies within this mantle with various factors of the micro-environment. (Daily macro-environmental data, including air …
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HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity
… Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the …
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Firefighter thermoregulation: clothingfit, cognition, and menthol
… which might result in a more favorable micro-environment during some phases of firefighting. Because of the potential for impaired cognition of the firefighters under stressful conditions, heat stress, and limited time to save victims, it is imperative to understand when cognition is …
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A History of the Professionalization of Interior Design: Viewed Through Three Case Studies of the Process of Licensure
… the primary focus of interior design was the micro-environment based on the theory of behavior. This gives students and practitioners a unique viewpoint that allows for the consideration for each end user as integral to the design process. These attributes contribute to the unique qualities of …
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In vitro permeability studies of antitumor compounds, thioxanthones across two model barriers, and their availability in vivo
… of tumors is their three dimensional structure (micro-environment), which forms a penetration barrier to anti-tumor agents. A drug has to cross the interstitial space of tumors and many layers of cells to reach the interior of a tumor. The main objective of this study was to develop two new in …
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Blacksburg Centre for the Arts: a proposed cultural center and town redevelopment
… of a methodology for generating a new environment for towns, using Blacksburg as an example of towns and a cultural center as the vehicle of generation. A need for a cultural center is established, and activities are programmed to fit that need. The idea is to create a center that will …
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Ultraportable surgical enclosure : human centered design for high usability in unpredictable environments
… is limited for many, especially those in austere environments and developing countries. SurgiBox is a product that aims to solve this problem by providing a sterile surgical micro-environment in a cost-effective manner. SurgiBox is a transparent, inflatable plastic enclosure which isolates the …
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Mobile Business as Strategic Tools in the US Airline Industry
… have to create a strategic fit with the business environment seen from an airline perspective. Forces inherent in the global environment as well as in the micro-environment are analyzed using environmental scanning as systematic technique. Exploratory data obtained from a focus group interview is …
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Marketing legal services to medium-sized companies
… this thesis examines forces in the macro- and micro-environment responsible for driving or hindering the development of strategic marketing initiatives in law firms. Taking the standpoint of medium-sized companies as corporate buyers of legal services, the thesis also examines purchasing …
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Robust numerical methods to solve differential equations arising in cancer modeling
… complex disease that involves a sequence of gene-environment interactions in a progressive process that cannot occur without dysfunction in multiple systems. From a mathematical point of view, the sequence of gene-environment interactions often leads to mathematical models which are hard to solve …
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Financial inclusion: A look at the institutional and credit organisational enablers in the South African market
… the hypothesis was 'some of the macro and micro enablers required when seeking to serve the underserved are missing in South Africa'. From our analysis; there are very specific positive steps being taken to enhance the macro environment. Hopefully as these undertakings are established the …
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3D printing of biological machines for biology and medicine
… consisting of living cells and cell-instructive micro-environments that interact to perform a prescribed task. Cell types such as neurons, muscle cells, and endothelial cells can be programmed for sensing, information processing, actuation, protein expression, or transport. By combining clusters …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
… monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory (M1) and anti-inflammatory (M2a, M2b, and M2c) subsets. Whether macrophage subset generation in chronic HCV infection …
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Semi-Open Space and Micro-Environmental Control for Improving Thermal Comfort, Indoor Air Quality, and Building Energy Efficiency
… space or SOS) have the potential to provide micro-environment that is tailored to the individual preference of the occupants, and hence increase the percentage of satisfied occupancy from currently 80% to near 100%. This research investigates the use of a micro-environmental control system …
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Investigating The Role of Exosomal Communication In The Glioma Microenvironment
… understood. We have recently shown that the micro-environment of human gliomas, the most aggressive human brain tumors, contains both glioma stem cells (GSCs) and cells that resemble human bone marrow-derived mesenchymal stem cells (BM-MSCs), called Glioma Associated-MSCs (GA-MSCs). We have …
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The effects of lime on the decomposition of buried human remains. A field and laboratory based study for forensic and archaeological application.
… types of lime on cadaver decomposition and its micro-environment. Field and laboratory experiments using pigs as human body analogues were undertaken to obtain a better understanding of the taphonomic processes that govern lime burials. The changes observed in the experiments were related back …
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