Integrative mathematical modelling of drug responses in breast cancer PDTXs and ex vivo PDTCs

This thesis explores the integrative application of mathematical modelling and experimental approaches to investigate drug responses in breast cancer, utilising patient-derived tumour xenografts (PDTXs) and ex vivo PDTX-derived tumour cells (PDTCs). A robust biobank of over 100 PDTXs, encompassing diverse breast cancer subtypes, was expanded and genomically characterised. This collection captures the broad heterogeneity of breast cancer, facilitating pre-clinical studies into tumour biology and therapeutic efficacy.

Name dc:type.qualificationname

Doctor of Philosophy (PhD)

Level dc:type.qualificationlevel

Doctoral

Grantor dc:publisher.institution

University of Cambridge

Year dc:date.issued

2025

Author dc:creator

• Guerrero Romero, Daniel

Advisors dc:contributor.advisor

• Caldas, Carlos
• Rueda, Oscar
• Markowetz, Florian

• Breast Cancer
• PDTXs
• PDTCs
• Mathematical modelling
• Biostatistics
• Drug response
• High-throughput drug screening

Licence

• https://www.repository.cam.ac.uk/bitstreams/6ba05cd5-e660-40e0-a22d-1d95588102a2/download
• http://purl.org/NET/rdflicense/allrightsreserved

DOI dc:identifier.doi

https://doi.org/10.17863/CAM.119013

OAI identifier oai:identifier

oai:www.repository.cam.ac.uk:1810/385396