Integrative mathematical modelling of drug responses in breast cancer PDTXs and ex vivo PDTCs
This thesis explores the integrative application of mathematical modelling and experimental approaches to investigate drug responses in breast cancer, utilising patient-derived tumour xenografts (PDTXs) and ex vivo PDTX-derived tumour cells (PDTCs). A robust biobank of over 100 PDTXs, encompassing diverse breast cancer subtypes, was expanded and genomically characterised. This collection captures the broad heterogeneity of breast cancer, facilitating pre-clinical studies into tumour biology and therapeutic efficacy.
Breast Cancer, PDTXs, PDTCs, Mathematical modelling, Biostatistics, Drug response, High-throughput drug screening
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