Integrative mathematical modelling of drug responses in breast cancer PDTXs and ex vivo PDTCs
type: CreativeWork
description: This thesis explores the integrative application of mathematical modelling and experimental approaches to investigate drug responses in breast cancer, utilising patient-derived tumour xenografts (PDTXs) and ex vivo PDTX-derived tumour cells (PDTCs). A robust biobank of over 100 PDTXs, encompassing diverse breast cancer subtypes, was expanded and genomically characterised. This collection captures the broad heterogeneity of breast cancer, facilitating pre-clinical studies into tumour biology and therapeutic efficacy.
abstract: This thesis explores the integrative application of mathematical modelling and experimental approaches to investigate drug responses in breast cancer, utilising patient-derived tumour xenografts (PDTXs) and ex vivo PDTX-derived tumour cells (PDTCs). A robust biobank of over 100 PDTXs, encompassing diverse breast cancer subtypes, was expanded and genomically characterised. This collection captures the broad heterogeneity of breast cancer, facilitating pre-clinical studies into tumour biology and therapeutic efficacy.
author: Guerrero Romero, Daniel
keywords: Breast Cancer, PDTXs, PDTCs, Mathematical modelling, Biostatistics, Drug response, High-throughput drug screening
license: https://www.repository.cam.ac.uk/bitstreams/6ba05cd5-e660-40e0-a22d-1d95588102a2/download
license: http://purl.org/NET/rdflicense/allrightsreserved
date published: 2025-02-03
date modified: 2026-07-22T22:23:56Z
provider: Cambridge University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Cambridge

PropertyValue
property ID: DOI
value: 10.17863/CAM.119013