Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"PDTXs"”.
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Integrative mathematical modelling of drug responses in breast cancer PDTXs and ex vivo PDTCs
… utilising patient-derived tumour xenografts (PDTXs) and ex vivo PDTX-derived tumour cells (PDTCs). A robust biobank of over 100 PDTXs, encompassing diverse breast cancer subtypes, was expanded and genomically characterised. This collection captures the broad heterogeneity of breast cancer, …
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Tumour ecology of breast cancer patient-derived xenografts
… models, patient-derived tumour xenografts (PDTXs) have been largely excluded from ecological descriptions due to the absence of a human TME and to the immune-compromised status of the mouse host. Evidence however suggests that PDTXs might be good candidates for ecosystem analyses because …
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Preclinical Modelling of Breast Cancer Drug Responses
… disease. Patient-derived tumour xenografts (PDTXs) have been found to recapitulate the main genomic and histological features of breast cancer and reflect the diversity of drug responses observed in the clinic. This thesis outlines the key findings on the development of an avatar co-clinical …