Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods

Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the response of human erythrocytes to the hydrolyzing action of secretory phospholipase A2 and the relationship between the susceptibility of hydrolysis and the physical properties of secretory phospholipase A2. Furthermore, we use models to determine the ability of calcium ionophore to increased membrane susceptibility.

Name thesis:degree_name

MS

Grantor dc:publisher

Brigham Young University - Provo

Author dc:creator

• Dozier, Zijun Lan

• phospholipase A2
• membrane susceptibility
• Monte Carlo
• Mathematics

Language dc:language

English

Repository record dc:identifier

https://scholarsarchive.byu.edu/etd/1387

OAI identifier oai:identifier

oai:scholarsarchive.byu.edu:etd-2386