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Showing 1 to 8 of 8 for “"lipid order"”.
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The Influence of Membrane Lipid Order on Cell Shape and Microvesiculation in Human Erythrocytes
… microscopic membrane physical properties such as lipid order. To test this hypothesis, membrane properties were manipulated by varying the experimental temperature, membrane cholesterol content, and the internal ionic environment. Changes in membrane order were assessed using steady-state …
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Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods
… investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the …
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Effect of aging on metabolic status and hormone responsiveness in the ovary
… additional glucose. We then evaluated membrane lipid order to determine whether animal age affects the membrane structure of granulosa cells. Membrane lipid structure including formation of raft microdomains may affect signaling by receptors involved in reproductive and metabolic functions. …
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Structure and Dynamics of Biomembranes containing Cholesterol and other Biologically-Important Sterols : a computational perspective
… MD simulations of hydrated sterol:DPPC lipid systems are performed at a biologically-relevant concentration (40\% mol.) at 309K and 323K. The simulations are compared with control simulations of the gel and liquid DPPC phases. All three sterols are found to order and condense the lipids …
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Development of new tools to study drug-lipid interactions and their application to investigating amphotericin b's association with model cell membranes
… cell membrane systems were used: sterol-free lipid monolayers adsorbed to a Hg electrode and sterol-free or sterol-containing floating lipid monolayers on a Langmuir trough. Electrochemical control over the adsorbed monolayer allowed the defectiveness of the layer to be varied and the …
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Relating phase separation and thickness mismatch in model lipid membranes.
Membrane lipids can spontaneously undergo a process called phase separation wherein they organize into domains with different compositions. Phase separation has been proposed as a mechanism in the formation of heterogeneous lipid regions (e.g. rafts) in cell membranes. The activity and partitioning …
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The effects of altered membrane fatty acid composition on the toxic interactions of heavy metals with Saccharomyces Cerevisiae
… fatty acids in whole-cell and plasma membrane lipids, and nuclear membrane lipids, respectively. Incorporation of the exogenous PUF As had no discernible adverse effects on cell division. However, inhibition of cell division in the presence of Cd(N03)2 was accentuated by growth in the presence …
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Protein-lipid interactions in raft-exhibiting membranes probed by combined AFM and FCS
… far from being an inert assembly of protein and lipids which separates cells from the surrounding environment. A multitude of biological processes, ranging from active transport of ions into and out of the cell, to the immune response, are regulated at the level of the plasma membrane. The …