{"id":{"repo_id":"byu","oai_identifier":"oai:scholarsarchive.byu.edu:etd-2386"},"canonical_url":"https://search.dev.ndltd.org/etd/byu/oai:scholarsarchive.byu.edu:etd-2386","repository":{"repo_id":"byu","name":"Brigham Young University","base_url":"https://scholarsarchive.byu.edu/do/oai/"},"display":{"title":"Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods","abstract":"Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the response of human erythrocytes to the hydrolyzing action of secretory phospholipase A2 and the relationship between the susceptibility of hydrolysis and the physical properties of secretory phospholipase A2. Furthermore, we use models to determine the ability of calcium ionophore to increased membrane susceptibility.","abstract_html":"Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the response of human erythrocytes to the hydrolyzing action of secretory phospholipase A2 and the relationship between the susceptibility of hydrolysis and the physical properties of secretory phospholipase A2. Furthermore, we use models to determine the ability of calcium ionophore to increased membrane susceptibility.","abstract_has_math":false,"creators":["Dozier, Zijun Lan"],"institution":"Brigham Young University - Provo","degree_name":"MS","degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-07-24T01:29:12Z","subjects":["phospholipase A2","membrane susceptibility","Monte Carlo","Mathematics"],"languages":["English"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsarchive.byu.edu/etd/1387","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Dozier, Zijun Lan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2008-05-23T07:00:00Z"]},{"key":"dc:publisher","label":"Institution","values":["Brigham Young University - Provo"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["MS"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["phospholipase A2","membrane susceptibility","Monte Carlo","Mathematics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsarchive.byu.edu/etd/1387","https://scholarsarchive.byu.edu/context/etd/article/2386/viewcontent/ETD_CISOPTR_1391.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Physical and Mathematical Sciences; Mathematics"]},{"key":"dc:description.abstract","label":"Abstract","values":["Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the response of human erythrocytes to the hydrolyzing action of secretory phospholipase A2 and the relationship between the susceptibility of hydrolysis and the physical properties of secretory phospholipase A2. Furthermore, we use models to determine the ability of calcium ionophore to increased membrane susceptibility."]},{"key":"dc:format","label":"Dc Format","values":["application:pdf"]},{"key":"dc:source","label":"Dc Source","values":["Brigham Young University - Provo"]},{"key":"dc:title","label":"Title","values":["Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods"]}]}],"canonical_facts":{"dc:creator":["Dozier, Zijun Lan"],"dc:date":["2008-05-23T07:00:00Z"],"dc:description":["Physical and Mathematical Sciences; Mathematics"],"dc:description.abstract":["Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the response of human erythrocytes to the hydrolyzing action of secretory phospholipase A2 and the relationship between the susceptibility of hydrolysis and the physical properties of secretory phospholipase A2. Furthermore, we use models to determine the ability of calcium ionophore to increased membrane susceptibility."],"dc:format":["application:pdf"],"dc:identifier":["https://scholarsarchive.byu.edu/etd/1387","https://scholarsarchive.byu.edu/context/etd/article/2386/viewcontent/ETD_CISOPTR_1391.pdf"],"dc:language":["English"],"dc:publisher":["Brigham Young University - Provo"],"dc:source":["Brigham Young University - Provo"],"dc:subject":["phospholipase A2","membrane susceptibility","Monte Carlo","Mathematics"],"dc:title":["Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods"],"dc:type":["Thesis"],"thesis:degree_name":["MS"]},"updated_at":"2026-07-24T01:29:12Z"}