EFFECTS OF A 3-DAY HIGH FAT VS HIGH CARBOHYDRATE DIET ON SERUM LEPTIN LEVELS, AND PERCEIVED FATIGUE IN MILD-TO-MODERATE MULTIPLE SCLEROSIS

Multiple Sclerosis is an immune mediated, chronic inflammatory disease of the central nervous system. The adipokine Leptin has been identified as a potential link between nutritional status and neuroendocrine and immune function. Leptin up-regulates a pro-inflammatory immune response. Fatigue is the most common and debilitating symptom of Multiple Sclerosis (MS). It is important to explore potential treatments as MS-related fatigue negatively affects the quality of life of persons with MS.1 While the exact cause of MS –related fatigue is unknown, there are numerous hypotheses indicating that diet may be associated with MS-related fatigue, and improved patient outcomes. To date there are no intervention studies comparing the effects of a high fat, low carbohydrate diet versus high carbohydrate, low fat diet on serum Leptin levels and secondly on MS related fatigue. The specific aim of this randomized, controlled, crossover study is to first investigate differences in serum Leptin in Multiple Sclerosis versus healthy control subjects. Secondly to investigate the effects of a high fat or high carbohydrate diet on serum Leptin levels, and MS related fatigue.

Grantor dc:publisher

State University of New York at Buffalo

Year dc:date.issued

2018

Author dc:creator

• DeSantis, Noelle

Contributors dc:contributor

• Ray, Andrew
• Exercise and Nutrition Sciences

• nutrition

Statement dc:rights

• Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.
• Copyright retained by author.

Language dc:language

eng

Handle dc:identifier

http://hdl.handle.net/10477/78032

OAI record oai:identifier

https://ubir.buffalo.edu/oai/request?verb=GetRecord&metadataPrefix=qdc&identifier=oai%3Aubir.buffalo.edu%3A10477%2F78032