The Effect of Skewed Elevation in dNTP pools on Loss of Heterozygosity in Saccharomyces cerevisiae

DNA precursors, deoxyribonucleotide triphosphates (dNTP), are the basic components of DNA. Enzyme ribonucleotide reductase (RNR) tightly regulates the levels of dNTP pools to ensure high fidelity DNA replication and repair. Misregulated levels of dNTP pools cause mutagenesis which impacts genome stability and cellular fitness; characteristics of cancer cells. Even though, a basic causal relationship between elevated dNTP pools and genomic instability has been established, some of the underlying mechanisms remain poorly understood.

Grantor dc:publisher

State University of New York at Buffalo

Year dc:date.issued

2018

Author dc:creator

• Badar, Jumana

Contributors dc:contributor

• Surtees, Jennifer
• Genetics, Genomics and Bioinformatics

• biochemistry

Statement dc:rights

• Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.
• Copyright retained by author.

Language dc:language

eng

Handle dc:identifier

http://hdl.handle.net/10477/78019

OAI record oai:identifier

https://ubir.buffalo.edu/oai/request?verb=GetRecord&metadataPrefix=qdc&identifier=oai%3Aubir.buffalo.edu%3A10477%2F78019