{"id":{"repo_id":"buffalo","oai_identifier":"oai:ubir.buffalo.edu:10477/78019"},"canonical_url":"https://search.dev.ndltd.org/etd/buffalo/oai:ubir.buffalo.edu:10477/78019","repository":{"repo_id":"buffalo","name":"Buffalo","base_url":"https://ubir.buffalo.edu/oai/request"},"display":{"title":"The Effect of Skewed Elevation in dNTP pools on Loss of Heterozygosity in Saccharomyces cerevisiae","abstract":"M.S.","abstract_html":"M.S.","abstract_has_math":false,"creators":["Badar, Jumana"],"institution":"State University of New York at Buffalo","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Surtees, Jennifer","Genetics, Genomics and Bioinformatics"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-06-28T20:32:41Z","date_published":"2018-06-28T20:32:41Z","updated_at":"2026-07-27T19:05:07Z","subjects":["biochemistry"],"languages":["eng"],"rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10477/78019","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Surtees, Jennifer","Genetics, Genomics and Bioinformatics"]},{"key":"dc:creator","label":"Author","values":["Badar, Jumana"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-06-28T20:32:41Z","2018","2018-05-15 07:40:28"]},{"key":"dc:publisher","label":"Institution","values":["State University of New York at Buffalo"]},{"key":"dc:type","label":"Dc Type","values":["Text","Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["biochemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/10477/78019"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["M.S.","DNA precursors, deoxyribonucleotide triphosphates (dNTP), are the basic components of DNA. Enzyme ribonucleotide reductase (RNR) tightly regulates the levels of dNTP pools to ensure high fidelity DNA replication and repair. Misregulated levels of dNTP pools cause mutagenesis which impacts genome stability and cellular fitness; characteristics of cancer cells. Even though, a basic causal relationship between elevated dNTP pools and genomic instability has been established, some of the underlying mechanisms remain poorly understood."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["The Effect of Skewed Elevation in dNTP pools on Loss of Heterozygosity in Saccharomyces cerevisiae"]}]}],"canonical_facts":{"dc:contributor":["Surtees, Jennifer","Genetics, Genomics and Bioinformatics"],"dc:creator":["Badar, Jumana"],"dc:date":["2018-06-28T20:32:41Z","2018","2018-05-15 07:40:28"],"dc:description":["M.S.","DNA precursors, deoxyribonucleotide triphosphates (dNTP), are the basic components of DNA. Enzyme ribonucleotide reductase (RNR) tightly regulates the levels of dNTP pools to ensure high fidelity DNA replication and repair. Misregulated levels of dNTP pools cause mutagenesis which impacts genome stability and cellular fitness; characteristics of cancer cells. Even though, a basic causal relationship between elevated dNTP pools and genomic instability has been established, some of the underlying mechanisms remain poorly understood."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/10477/78019"],"dc:language":["eng"],"dc:publisher":["State University of New York at Buffalo"],"dc:rights":["Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions.","Copyright retained by author."],"dc:subject":["biochemistry"],"dc:title":["The Effect of Skewed Elevation in dNTP pools on Loss of Heterozygosity in Saccharomyces cerevisiae"],"dc:type":["Text","Thesis"]},"updated_at":"2026-07-27T19:05:07Z"}