Resolvin E1 actions on polymorphonuclear neutrophils in diabetes

Diabetes and periodontal disease exhibit a bidirectional relationship centered on an enhanced inflammatory response manifested both locally and systemically. The observation that hyperglycemia by itself, in the absence of additional inflammatory signals, promotes a proinflammatory environment indicates that diabetes is an independent risk factor for periodontal disease. Leukocyte pre-activation or priming in diabetes has been demonstrated. Excessive ROS release by leukocytes, upregulation of pro-inflammatory mediators and adhesion molecules are characteristic to T2DM-associated low-grade inflammation. However, the mechanisms by which chronic hyperglycemia leads to leukocyte activation are not fully understood. [TRUNCATED]

Grantor dc:publisher

Boston University

Year dc:date.issued

2010

Author dc:creator

• Sima, Corneliu

• Eicosapentaenoic acid
• Periodontal diseases
• Neutrophils
• Hyperglycemia
• Mice

Statement dc:rights

• This work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/2144/32698

OAI identifier oai:identifier

oai:open.bu.edu:2144/32698