Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Resolvin"”.
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Computational analysis and partialsynthesis of resolvin analogues
An introduction to the role of resolvins in inflammation is outlined in Chapter 1. In addition, a literature survey of the structure-activity relationships of resolvins, protectins and maresins is also included. Chapter 2 briefly outlines the aims and objectives of this project. Chapter 3 focuses …
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Resolvin E1 actions on polymorphonuclear neutrophils in diabetes
Diabetes and periodontal disease exhibit a bidirectional relationship centered on an enhanced inflammatory response manifested both locally and systemically. The observation that hyperglycemia by itself, in the absence of additional inflammatory signals, promotes a proinflammatory environment …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… Hydrophobic drugs such as cyclosporine, resolvin analog (RX-10045), dexamethasone, rapamycin were entrapped in the core of polymeric micelles and solubilized. Polymeric amphiphilic molecules (e.g., hydrogenated castor oil – 40 (HCO-40) and Vit. E TPGS) are known to generate nanomicellar …
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Evaluation of immunomodulatory mediators in chronic obstructive pulmonary disease and cardiovascular disease
… (IL-33)/ST2 axis and secondly, specialised pro-resolving mediators (SPMs), specifically the specialised pro-resolving mediator Resolvin D1. Additionally, data pertaining to the anti-platelet drug aspirin in people with COPD was evaluated. The reason for this was to evaluate if aspirin may have …
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Changes in tear film biochemistry in end of day ocular discomfort with and without contact lenses
… protein, proline rich protein 4, resolvin D1 and C3a are reported for the first time. Concentrations of lysozyme and lactoferrin, secretory phospholipase A2, bradykinin, prostaglandins, cysteinyl leukotrienes, resolvin D1, phosphatidylcholines, lysophosphatidylcholines, …
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Immunomodulatory biomaterials to promote early transplant integration and wound healing
… biomaterial system to deliver Aspirin-Triggered Resolvin D1 and Interleukin-10 in murine models of cutaneous injury and skin transplantation. We demonstrated that injured tissue can be enriched with anti-inflammatory, pro-angiogenic and pro-regenerative populations of neutrophils, monocytes, and …
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Impact of Epa and Dha Supplementation and 15-Lox-1 Expression On Colitis and Colitis-Associated Colorectal Cancer
… acid (EPA) and docosahexaenoic acid (DHA) to resolvins, potent anti-inflammatory products. 15-LOX-1 effects on the conversion of EPA and DHA to resolvins that subsequently exert anti-inflammatory and anti-tumorigenic effects have received little attention. To address this knowledge gap, we …
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Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
… exogenous RONS can initiate the production of resolvin D1 by concurrently increasing the expression of its biosynthetic enzymes and its receptor through TLR4 stimulation. Our data show that exogenous RONS-induced TLR4 stimulation plays a critical role in activating both proinflammatory and …
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Effects of dietary intervention on inflammation and intrauterine growth restriction in neonatal piglets
… in vivo, nor did it affect fever or circulating resolvin D1 levels. HRO may have created a more neuroprotective microglial phenotype in vivo, as C-X-C motif chemokine ligand 16 (CXCL16), transforming growth factor beta receptor 1 (TGFBR1), and complement component C1QA were upregulated. The …