Investigação dos efeitos antibacteriano e citotóxico de cumarinas

Biologically active natural products can be of vegetable, animal and mineral, although there is a predominance of plant resources. These represent a rich source of biologically active compounds and are an example of molecular diversity. Amburana cearensis is a genus of Brazilian plants, specificall y the Northeast popularly known as Cumaru - do - ceará and amburana. The chemical and pharmacological analysis of this plant have shown the presence of coumarins as one of the most abundant chemical components which is probably responsible, together with other substances, the beneficial effect of infusions of shells. Coumarins are derived from the metabolism of phenylalanine, taking as initial precursors cinnamic acid and p - hydroxy cinnamic acid, from which coumarins and their derivatives are biosynthesized by different routes. The potency of antibiotics is threatened by bacterial resistance, increasing the need for new drugs and new classes of antibiotics. The erythrocytes have been used as a model for evaluating the protective and toxic effects of a large vari ety of substances allowing to obtain information on the effects of the cell membrane. Thus the aim of the study was to evaluate the toxicity profile of some coumarins ( 1,2 - benzopirona and 4 - coumarinol ) was conducted to determine the cytotoxic potential aga inst human erythrocytes of groups A, B and O, as the cytotoxic potential against bacteria of clinical importance, which was evaluated by determining the minimum inhibitory concentration (MIC) by microdilution technique. Coumarins A. cearensis were able to induce hemolysis of human red cells belonging to the three ABO blood types, however at very low percentages, not compromising its fundamental role of gas transport in the body. 1,2 - benzopirona and 4 - coumarinol , coumarins A. cearensis showed antimicrobial e ffect forward Gram positive and Gram negative strains with a minimum inhibitory concentration ranging between 6,7 μg and 200 μg. This result is relevant since Gram positive bacteria are generally more sensitive to antibiotics than gram - negative bacteria. The integrity of the cell membrane depends on the cell tone and substances that can interfere with the membrane matr ix, however the coumarin A. cearensis did not change the operation of the membrane of human erythrocytes

Grantor dc:publisher

Universidade Federal da Paraíba

Year dc:date.issued

2015

Author dc:creator

• Alves, Ruhama Estevam

• Antimicrobiana
• Cittoxicidade
• Amburana Cearensis
• Cumarina

Language dc:language.iso

pt

Repository record dc:identifier.uri

https://repositorio.ufpb.br/jspui/handle/123456789/945

OAI identifier oai:identifier

oai:repositorio.ufpb.br:123456789/945