Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos

Piperine is the major alkaloid of Piper nigrum Linn., used as spice and in popular medicine. We present a molecular docking study supporting experimental data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain the related mechanism of interaction drug - herb, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug - enzyme interaction, increasing th e bioavailability of the considered drugs.

Grantor dc:publisher

Universidade Federal da Paraíba

Year dc:date.issued

2016

Author dc:creator

• Oliveira, Ramon Guerra de

• Piperina
• Inibição Enzimática
• Docking Molecular
• CYP3A4

Language dc:language.iso

pt

Repository record dc:identifier.uri

https://repositorio.ufpb.br/jspui/handle/123456789/1007

OAI identifier oai:identifier

oai:repositorio.ufpb.br:123456789/1007