{"id":{"repo_id":"brazil-ufpb","oai_identifier":"oai:repositorio.ufpb.br:123456789/1007"},"canonical_url":"https://search.dev.ndltd.org/etd/brazil-ufpb/oai:repositorio.ufpb.br:123456789/1007","repository":{"repo_id":"brazil-ufpb","name":"Brazil UFPB","base_url":"https://repositorio.ufpb.br/oai/request"},"display":{"title":"Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos","abstract":"Piperine is the major alkaloid of Piper nigrum Linn., used as spice and in popular medicine. We present a molecular docking study supporting experimental data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain the related mechanism of interaction drug - herb, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug - enzyme interaction, increasing th e bioavailability of the considered drugs.","abstract_html":"Piperine is the major alkaloid of Piper nigrum Linn., used as spice and in popular medicine. We present a molecular docking study supporting experimental data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain the related mechanism of interaction drug - herb, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug - enzyme interaction, increasing th e bioavailability of the considered drugs.","abstract_has_math":false,"creators":["Oliveira, Ramon Guerra de"],"institution":"Universidade Federal da Paraíba","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-03-09","date_published":"2016-03-09","updated_at":"2026-07-24T01:18:05Z","subjects":["Piperina","Inibição Enzimática","Docking Molecular","CYP3A4"],"languages":["pt"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://repositorio.ufpb.br/jspui/handle/123456789/1007","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Oliveira, Ramon Guerra de"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-03-09T14:48:07Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-03-09T14:48:07Z"]},{"key":"dc:date.issued","label":"Date","values":["2016-03-09"]},{"key":"dc:publisher","label":"Institution","values":["Universidade Federal da Paraíba"]},{"key":"dc:type","label":"Dc Type","values":["TCC"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Piperina","Inibição Enzimática","Docking Molecular","CYP3A4"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["pt"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://repositorio.ufpb.br/jspui/handle/123456789/1007"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Piperine is the major alkaloid of Piper nigrum Linn., used as spice and in popular medicine. We present a molecular docking study supporting experimental data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain the related mechanism of interaction drug - herb, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug - enzyme interaction, increasing th e bioavailability of the considered drugs."]},{"key":"dc:title","label":"Title","values":["Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos"]}]}],"canonical_facts":{"dc:creator":["Oliveira, Ramon Guerra de"],"dc:date.accessioned":["2016-03-09T14:48:07Z"],"dc:date.available":["2016-03-09T14:48:07Z"],"dc:date.issued":["2016-03-09"],"dc:description.abstract":["Piperine is the major alkaloid of Piper nigrum Linn., used as spice and in popular medicine. We present a molecular docking study supporting experimental data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain the related mechanism of interaction drug - herb, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug - enzyme interaction, increasing th e bioavailability of the considered drugs."],"dc:identifier.uri":["https://repositorio.ufpb.br/jspui/handle/123456789/1007"],"dc:language.iso":["pt"],"dc:publisher":["Universidade Federal da Paraíba"],"dc:subject":["Piperina","Inibição Enzimática","Docking Molecular","CYP3A4"],"dc:title":["Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos"],"dc:type":["TCC"]},"updated_at":"2026-07-24T01:18:05Z"}