Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos
type: CreativeWork
description: Piperine is the major alkaloid of Piper nigrum Linn., used as spice and in popular medicine. We present a molecular docking study supporting experimental data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain the related mechanism of interaction drug - herb, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug - enzyme interaction, increasing th e bioavailability of the considered drugs.
abstract: Piperine is the major alkaloid of Piper nigrum Linn., used as spice and in popular medicine. We present a molecular docking study supporting experimental data about the enhance in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain the related mechanism of interaction drug - herb, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug - enzyme interaction, increasing th e bioavailability of the considered drugs.
author: Oliveira, Ramon Guerra de
language: pt
keywords: Piperina, Inibição Enzimática, Docking Molecular, CYP3A4
date published: 2016-03-09
date modified: 2026-07-24T01:18:05Z
provider: Brazil UFPB
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Universidade Federal da Paraíba