Towards the synthesis of ferrocene nucleic acids

The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also investigated as monomer precursors for DNA synthesis.

Name dc:type.qualificationname

m_rs

Level dc:type.qualificationlevel

m_rs

Grantor dc:publisher.institution

University of Birmingham

Year dc:date.issued

2009

Author dc:creator

• Lydon, Claire Elizabeth

• QD Chemistry