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Showing 1 to 20 of 918 for “"nucleic"”.
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Nucleic acid biosensors
… volume element, as well as sophisticated nucleic acid sensors. A flow cell based microsphere platform (electronic tongue), and a novel hydrogel platform based on shape recognition elements (MUFFINS), have been combined with nucleic acid sensors (ssDNA and aptamers) and fluorescence …
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Molecular Recognition of Nucleic Acids
Part II presents the design and attempted synthesis of several novel nucleosides that were intended to hydrogen bond to Watson-Crick base pairs in the major groove of DNA. The geometry of the connection of these heterocycles to the ribose backbone was designed to be isomorphous with the T$\cdot$AT …
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Unexpected mechanical properties of nucleic acids
Mechanical deformations of nucleic acids (NA) play a very important role in many biological life processes. The bending persistence length of DNA is of specific interest, because so much eukaryotic DNA that stores genetic information is tightly packed inside cell nuclei, even though DNA is …
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Computational prediction of allosteric nucleic acids
Selected nucleic acid binding species (aptamers) have been shown to undergo conformational changes in the presence of ligands, and have been adapted to function as biosensors. We were interested in whether the secondary structures of aptamers could be rationally engineered to undergo ligand …
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Synthesis of aromatic peptide nucleic acids
… synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties of PNAs in addition to a more hydrophobic …
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Chemical Studies on Nucleic Acid Analogues
Dicarbonyl aldehydes are known to react preferentially with guanine residues in both DNA and RNA; however, the exact structure of the modification product has never been assigned unequivocally as either the "linear" or the "bent" isomer. Accordingly, we have synthesized the products of guanine …
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Molecular recognition of nucleic acid components
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1992.
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Prebiotic assembly and replication of nucleic acids
… as the "RNA world", relies on replication of ribonucleic acid (RNA) before the advent of protein enzymes and deoxyribonucleic acid (DNA). Essentially, the hypothesis relies on what some researchers believe is a parsimonious claim that RNA was the central molecule of heredity and metabolic …
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An investigation into nucleic acid binding compounds
… with protein function; few drugs target the nucleic acid structures of DNA or RNA. Since these structures are underutilised as drug targets by comparison to proteins, it is desirable to design new antibiotics that target them. This allows new mechanisms of action to be explored and thus …
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Nucleic acid denaturation at an electrode surface
… the electrode surface. It was found that peptide nucleic acid (an uncharged analogue of DNA) could be denatured electrochemically. Local pH changes were also ruled-out as a possible mechanism through experiments in which the surface pH and electrochemical melting were monitored …
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Ribose nucleic acid and the cell nucleus
1. Methods of estimation of ribose nucleic acid are discussed and a reliable method for the estimation of that substance in isolated cell nuclei described.
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Programming Molecular Devices using Nucleic Acid Hairpins
<p>Nucleic Acid hairpins have been a subject of study for the last four decades. They are composed of single strand that is </p><p>hybridized to itself, and the central section forming an unhybridized loop. In nature, they stabilize single stranded RNA, serve as nucleation</p><p>sites for RNA …
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Towards the synthesis of ferrocene nucleic acids
The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised …
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Metabolism of Exogenous Nucleic Acids by Ovines
Made available in DSpace on 2014-12-10T22:30:20Z (GMT). No. of bitstreams: 1 7121095.pdf: 2699265 bytes, checksum: 264f51ee1619d349e882f25cceb964da (MD5) Previous issue date: 1971
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Nucleic acid-templated assembly of therapeutic agents
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Cas protein diagnostics for pathogen nucleic acids
Cas protein diagnostics for pathogen nucleic acids - Akashaditya Das I formulated my research goals for my PhD in tandem with a Global Challenges Research Grant awarded to the Ajioka Lab in collaboration with other labs in the United Kingdom and South Africa. The grant aimed to develop tests for …
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Silaffin Tagged Polymerase for Nucleic Acid Amplification
… (blood) when compared to more standard nucleic acid amplification diagnostic methods. In addition, this thesis initiates consideration of an extremely thermostable red fluorescent protein through structural analysis of mCherry and thermal green protein (TGP) for future integration with …
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Developing Nucleic Acid-Based Sensors and Actuators
… of regulatory logic in complex environments. Nucleic acids are attractive molecules for designing sense-and-respond modules: they are ubiquitous, information-rich and interact with each other through simple rules. Here, through two examples, I show that nucleic acids are particularly suited to …
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Artificial and natural nucleic acid self assembling systems
<p>Nucleic acids are good candidates for nanomachine construction. They participate in all the processes of life, and so can function as structural building blocks and dynamic catalysts. However, to use nucleic acids as nanomachines, a better understanding of their material properties, how to …
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