{"id":{"repo_id":"birmingham","oai_identifier":"oai:etheses.bham.ac.uk:1248"},"canonical_url":"https://search.dev.ndltd.org/etd/birmingham/oai:etheses.bham.ac.uk:1248","repository":{"repo_id":"birmingham","name":"University of Birmingham","base_url":"https://etheses.bham.ac.uk/cgi/oai2"},"display":{"title":"Towards the synthesis of ferrocene nucleic acids","abstract":"The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also investigated as monomer precursors for DNA synthesis.","abstract_html":"The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also investigated as monomer precursors for DNA synthesis.","abstract_has_math":false,"creators":["Lydon, Claire Elizabeth"],"institution":"University of Birmingham","degree_name":"m_rs","degree_level":"m_rs","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-12","date_published":"2009-12","updated_at":"2026-07-24T01:11:26Z","subjects":["QD Chemistry"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.sponsor","label":"Sponsor","values":["na"]},{"key":"dc:creator","label":"Author","values":["Lydon, Claire Elizabeth"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2009-12-11"]},{"key":"dc:date.issued","label":"Date","values":["2009-12"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["College of Engineering & Physical Sciences","School of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Birmingham"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["http://etheses.bham.ac.uk//id/eprint/1248/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["m_rs"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["m_rs"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["QD Chemistry"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://etheses.bham.ac.uk//id/eprint/1248/1/Lydon09MRes.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also investigated as monomer precursors for DNA synthesis."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Towards the synthesis of ferrocene nucleic acids"]}]}],"canonical_facts":{"dc:contributor.sponsor":["na"],"dc:creator":["Lydon, Claire Elizabeth"],"dc:date":["2009-12-11"],"dc:date.issued":["2009-12"],"dc:description.abstract":["The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised using MALDI-ToF Mass Spectrometry. CD and Tm studies were also carried out. Synthetic strategies towards chiral ferrocenes, via intermediates with groups consisting of protected alcohols or amines on each of the cyclopentadienyl rings, were also investigated as monomer precursors for DNA synthesis."],"dc:format":["application/pdf"],"dc:identifier.uri":["http://etheses.bham.ac.uk//id/eprint/1248/1/Lydon09MRes.pdf"],"dc:publisher.department":["College of Engineering & Physical Sciences","School of Chemistry"],"dc:publisher.institution":["University of Birmingham"],"dc:relation.isreferencedby":["http://etheses.bham.ac.uk//id/eprint/1248/"],"dc:subject":["QD Chemistry"],"dc:title":["Towards the synthesis of ferrocene nucleic acids"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["m_rs"],"dc:type.qualificationname":["m_rs"]},"updated_at":"2026-07-24T01:11:26Z"}