Effects of Grain Sorghum Muffin on Blood Glucose and Insulin Responses in Prediabetic Men

<p>Prediabetes is a sub-health condition in the development to type 2 diabetes, which has been long overlooked. Grain sorghum contains functional starch fractions, which have been widely reported for their potential on blood glucose control and diabetes prevention. A human study with prediabetic men was conducted to investigate the effects of sorghum starch on postprandial blood glucose and insulin levels. Grain sorghum and wheat (control) muffins containing 50 g total starch were consumed by 15 prediabetic male subjects on two mornings with a 1-week washout period. Plasma samples were collected on -15 (baseline), 0, 15, 30, 45, 60, 75, 90, 120, and 180 minutes after each treatments. The functional starch content (SDS and RS combined) of grain sorghum muffin was higher than control muffin. Postprandial blood glucose and insulin responses were both significantly reduced on 45 - 120 min intervals (p<0.05). With the grain sorghum muffin treatment, the mean incremental area under the curve (iAUC) of glucose was significantly reduced by 35.0%, from 5457.5 ± 645.4 to 3550.0 ± 428.9 mg (~3 h) dL-1 (P<0.05). The mean iAUC of insulin was also significantly lowered by 36.7%, from 7254.6 ± 1228.9 to 4589.3 ± 737.2 mU (~3 h) L-1 (p<0.05). The results implied that grain sorghum is a good candidate in controlling blood glucose and insulin levels in prediabetic population for the prevention of type 2 diabetes. </p>

Name thesis:degree_name

Master of Science in Food Science (MS)

Level thesis:degree_level

Thesis

Year dc:date.available

2014

Author dc:creator

• Gu, Xuan

Advisor dc:contributor.advisor

• Lee, Sun-Ok

Contributors dc:contributor

• Wang, Ya-Jane
• Gbur, Edward E. Jr.

• Blood Glucose
• Functional Starch
• Grain Sorghum
• Insulin
• Prediabetes
• Food Chemistry
• Human and Clinical Nutrition
• Molecular, Genetic, and Biochemical Nutrition

Repository record dc:identifier

https://scholarworks.uark.edu/etd/2025

OAI identifier oai:identifier

oai:scholarworks.uark.edu:etd-3564