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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1892 for “"Insulin"”.
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Insulin - Metal Complexes
Made available in DSpace on 2014-12-05T19:36:04Z (GMT). No. of bitstreams: 1 0010473.pdf: 2644605 bytes, checksum: f22f9842303a77e6ccde280acc539eb8 (MD5) Previous issue date: 1954
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Cardiovascular effects of insulin: studies in normal and insulin resistant subjects
Contains fulltext : mmubn000001_237863731.pdf (Publisher’s version ) (Open Access)
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The effect of an exercise intervention on insulin sensitivity, insulin secretion and insulin clearance in black obese South African women
… Black African populations present with low insulin sensitivity (SI) and hyperinsulinemia, the latter due to high insulin secretion and reduced clearance. In addition, they exhibit lower levels of central and ectopic fat, compared to their white counterparts, contradicting the known …
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Synthesis and characterisation of fluorescent FITC-insulin glulisine conjugates for insulin delivery
… from commercially available rapid-acting insulin glulisine (Apidra®) and the fluorescent dye FITC (Fluorescein Isothiocyanate) for comparison with the biological activity of native insulin glulisine. The first objective of the study was to produce a single-labelled fluorescent-insulin …
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Effects of Zinc on the Insulin Receptor and Insulin Signal Transduction Pathway
Zinc is reported to have insulin-like effects. However, the mechanism of these effects still remains unclear. In the present work, the ability of a divalent cation zinc, to modify binding characteristics of the human insulin and type 1 IGF receptors and the insulin intracellular signaling pathway …
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Controlled Release of Insulin and Modified Insulin from a Novel Injectable Biodegradable Gel
… a controlled release dosage form of <br />insulin, which can provide basal concentrations of insulin in diabetic rats for 1 to 2 weeks after a single subcutaneous injection. <br />A biodegradable injectable drug delivery gel was prepared by dissolving a <br />biodegradable polymer, …
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Criticality control of insulin release: a novel alternative for detailed modelling of insulin secretion
… of the dynamic components of the glucose-insulin system has posed a major challenge in the field of physiological modelling for the past six decades. Early stages in development focused on a descriptive approach where mathematical complexity was usually compromised, causing …
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Cloning and characterization of ovine insulin, insulin-like growth factor-I and -II genes
Genes encoding ovine insulin like growth factor-I (oIGF-D), -II (oIGF-II) and insulin were cloned, sequenced and characterized. The olGF-I gene contains six exons spanning greater than 30 kilobases. Class 1 and class 2 oIGF-I transcripts contained exons 1 and 2 alternatively-spliced to exon 3, …
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Human insulin: efficacy and immunogenicity
Contains fulltext : mmubn000001_028817273.pdf (Publisher’s version ) (Open Access)
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Quantitative Studies on Insulin Action
Made available in DSpace on 2014-12-05T19:37:39Z (GMT). No. of bitstreams: 1 6101593.pdf: 4060428 bytes, checksum: 64f0e56ec1ef39370b79f8b29654ad26 (MD5) Previous issue date: 1961
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A Comparative Analysis of Human Insulin versus Analog Insulin: Glycemic Control, Adherence, Utilization, and Cost-Effectiveness
… medicine for many patients with diabetes, insulin cost is growing out of reach for many. Of the two broad classes of insulin available in the US, analog insulin is newer, costlier, and more widely used than human insulin. The new mode of delivery with pen devices has shown promise in …
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Comparison of quality of life in diabetics using insulin injection therapy versus subcutaneous insulin infusion therapy
… this study was to determine the effectiveness of insulin delivered via multiple injections or by infusion via a pump on the quality of life in adult insulin-dependent diabetics. Four parameters, namely hemoglobin A1C (3 month average blood sugar levels), self-reported healthy eating habits …
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Glucose regulation in Thoroughbred weanlings: Regulation by insulin, growth hormone and insulin-like growth factor-I
… carbohydrates induce a hyperglycemic/insulinemic response and may increase the incidence of metabolic disorders associated with some types of laminitis, exertional rhabdomyolysis and osteochondrosis in horses. This study applied the minimal model of glucose and insulin dynamics to …
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Insulin adsorption to intravenous delivery systems
… a physician to determine the actual amount of insulin received by a patient against the amount added to the intravenous infusion system. This project was therefore initiated to determine quantitatively the extent of adsorption that would occur in a clinical setting.</p><p>In order to achieve …
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Metabolic studies in acute insulin deficiency
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Myocardial insulin resistance in experimental uraemia
… Progression of LVH leads to the development of insulin resistance, a feature common to CKD and heart failure, further jeopardising survival of the uraemic heart.The aim of this thesis was to investigate the effect of uraemia on cardiac physiology, function and metabolism. Specifically, the aim …
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Subcutaneous and oral delivery of insulin
… compare a subcutaneous/oral delivery system for insulin. The effect of various low molecular weight chitosans (LMWCs) on the stability of insulin, using USP HPLC methods, was investigated. Insulin was found to be stable in a polyelectrolyte complex (PEC) consisting of insulin and LMWC in the …
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Hyperglycaemia, insulin and acute ischaemic stroke
… to assess the effect of GKI (Glucose-Potassium-Insulin) versus placebo on lesion volume progression and cerebral lactate levels using magnetic resonance imaging (MRI) and spectroscopy (MRS). An observational study of the capillary blood glucose within 48 hours of stroke onset was performed to …
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Insulin: its assay, extraction and sources
… in the methods of extraction and purification of insulin followed quickly. Accompanying this were the investigations of the physiological, chemical and physical properties of the hormone. Since that time a mass of evidence relating to the above and produce by a host of workers has accumulated.
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