골경화성 골전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성

Bone metastasis is an important factor for treatment and prognosis of breast cancer patients. Whole body bone scintigraphy can be used to evaluated bone metastases and also F-18 FDG PET/CT seems to exhibit high specificity and accuracy to detect skeletal metastases. However there is the limitation of F-18 FDG PET in assessing sclerotic bone metastasis because the lesions can be undetectable. Recent studies showed that F-18 fluoride PET/CT is more sensitive than bone scintigraphy to detect bone metastasese. The aim of this study is to evaluate usefulness of F-18 fluoride PET/CT in breast cancer patients with skeletal metastasis by comparing with bone scintigraphy and F-18 FDG PET/CT. Seven breast cancer patients with metastasis (7 females; mean age ± SD, 53 ± 11 y) underwent bone scan, F-18 FDG PET/CT and F-18 fluoride PET/CT. The images were evaluated with visual analysis based on consensus reading by 2 experienced nuclear medicine physicians. Lesion-based analysis was performed in various regions of the skeletons (skull, vertebral column, thoracic cage, long bones and pelvic bones). A total of 88 metastatic bone lesions were found on F-18 fluoride PET/CT, 30 lesions on bone scintigraphy and 23 lesions on F-18 FDG PET/CT. Most lesions on F-18 fluoride PET/CT had osteosclerotic change (84/88, 95%) with only 4 lesions showed osteolytic change on corresponding CT images. The most lesions on F-18 FDG PET/CT also demonstrated sclerotic change (20/23, 87%) with 3 osteolytic lesions. All metastatic lesions detected on bone scintigraphy and F-18 FDG PET/CT were found on F-18 fluoride PET/CT. In conclusion, F-18 fluoride PET/CT is superior in detecting osteosclerotic metastatic lesions than other tools. F-18 fluoride PET/CT might be useful method to evaluate osteosclerotic metastasis in breast cancer patients.

Author dc:creator

• 윤, 석호

Contributors dc:contributor

• 안, 영실
• 대학원 의학과
• 200724298

• F-18 fluoride
• F-18 NaF
• PET/CT
• 유방암
• 골전이

Language dc:language

ko

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012216
000000012216

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/7575