{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/7575"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/7575","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"골경화성 골전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성","abstract":"Bone metastasis is an important factor for treatment and prognosis of breast cancer patients. Whole body bone scintigraphy can be used to evaluated bone metastases and also F-18 FDG PET/CT seems to exhibit high specificity and accuracy to detect skeletal metastases. However there is the limitation of F-18 FDG PET in assessing sclerotic bone metastasis because the lesions can be undetectable. Recent studies showed that F-18 fluoride PET/CT is more sensitive than bone scintigraphy to detect bone metastasese. The aim of this study is to evaluate usefulness of F-18 fluoride PET/CT in breast cancer patients with skeletal metastasis by comparing with bone scintigraphy and F-18 FDG PET/CT. Seven breast cancer patients with metastasis (7 females; mean age ± SD, 53 ± 11 y) underwent bone scan, F-18 FDG PET/CT and F-18 fluoride PET/CT. The images were evaluated with visual analysis based on consensus reading by 2 experienced nuclear medicine physicians. Lesion-based analysis was performed in various regions of the skeletons (skull, vertebral column, thoracic cage, long bones and pelvic bones). A total of 88 metastatic bone lesions were found on F-18 fluoride PET/CT, 30 lesions on bone scintigraphy and 23 lesions on F-18 FDG PET/CT. Most lesions on F-18 fluoride PET/CT had osteosclerotic change (84/88, 95%) with only 4 lesions showed osteolytic change on corresponding CT images. The most lesions on F-18 FDG PET/CT also demonstrated sclerotic change (20/23, 87%) with 3 osteolytic lesions. All metastatic lesions detected on bone scintigraphy and F-18 FDG PET/CT were found on F-18 fluoride PET/CT. In conclusion, F-18 fluoride PET/CT is superior in detecting osteosclerotic metastatic lesions than other tools. F-18 fluoride PET/CT might be useful method to evaluate osteosclerotic metastasis in breast cancer patients.","abstract_html":"Bone metastasis is an important factor for treatment and prognosis of breast cancer patients. Whole body bone scintigraphy can be used to evaluated bone metastases and also F-18 FDG PET/CT seems to exhibit high specificity and accuracy to detect skeletal metastases. However there is the limitation of F-18 FDG PET in assessing sclerotic bone metastasis because the lesions can be undetectable. Recent studies showed that F-18 fluoride PET/CT is more sensitive than bone scintigraphy to detect bone metastasese. The aim of this study is to evaluate usefulness of F-18 fluoride PET/CT in breast cancer patients with skeletal metastasis by comparing with bone scintigraphy and F-18 FDG PET/CT. Seven breast cancer patients with metastasis (7 females; mean age ± SD, 53 ± 11 y) underwent bone scan, F-18 FDG PET/CT and F-18 fluoride PET/CT. The images were evaluated with visual analysis based on consensus reading by 2 experienced nuclear medicine physicians. Lesion-based analysis was performed in various regions of the skeletons (skull, vertebral column, thoracic cage, long bones and pelvic bones). A total of 88 metastatic bone lesions were found on F-18 fluoride PET/CT, 30 lesions on bone scintigraphy and 23 lesions on F-18 FDG PET/CT. Most lesions on F-18 fluoride PET/CT had osteosclerotic change (84/88, 95%) with only 4 lesions showed osteolytic change on corresponding CT images. The most lesions on F-18 FDG PET/CT also demonstrated sclerotic change (20/23, 87%) with 3 osteolytic lesions. All metastatic lesions detected on bone scintigraphy and F-18 FDG PET/CT were found on F-18 fluoride PET/CT. In conclusion, F-18 fluoride PET/CT is superior in detecting osteosclerotic metastatic lesions than other tools. F-18 fluoride PET/CT might be useful method to evaluate osteosclerotic metastasis in breast cancer patients.","abstract_has_math":false,"creators":["윤, 석호"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["안, 영실","대학원 의학과","200724298"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-10-30T04:14:53Z","date_published":"2012-10-30T04:14:53Z","updated_at":"2026-07-24T00:51:39Z","subjects":["F-18 fluoride","F-18 NaF","PET/CT","유방암","골전이"],"languages":["ko"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012216","000000012216"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012216","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012216","code":true},{"text":"000000012216","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/7575","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["안, 영실","대학원 의학과","200724298","윤, 석호"]},{"key":"dc:creator","label":"Author","values":["윤, 석호"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2012-10-30T04:14:53Z","2012"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["F-18 fluoride","F-18 NaF","PET/CT","유방암","골전이"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ko"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/7575","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012216","000000012216"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bone metastasis is an important factor for treatment and prognosis of breast cancer patients. Whole body bone scintigraphy can be used to evaluated bone metastases and also F-18 FDG PET/CT seems to exhibit high specificity and accuracy to detect skeletal metastases. However there is the limitation of F-18 FDG PET in assessing sclerotic bone metastasis because the lesions can be undetectable. Recent studies showed that F-18 fluoride PET/CT is more sensitive than bone scintigraphy to detect bone metastasese. The aim of this study is to evaluate usefulness of F-18 fluoride PET/CT in breast cancer patients with skeletal metastasis by comparing with bone scintigraphy and F-18 FDG PET/CT. Seven breast cancer patients with metastasis (7 females; mean age ± SD, 53 ± 11 y) underwent bone scan, F-18 FDG PET/CT and F-18 fluoride PET/CT. The images were evaluated with visual analysis based on consensus reading by 2 experienced nuclear medicine physicians. Lesion-based analysis was performed in various regions of the skeletons (skull, vertebral column, thoracic cage, long bones and pelvic bones). A total of 88 metastatic bone lesions were found on F-18 fluoride PET/CT, 30 lesions on bone scintigraphy and 23 lesions on F-18 FDG PET/CT. Most lesions on F-18 fluoride PET/CT had osteosclerotic change (84/88, 95%) with only 4 lesions showed osteolytic change on corresponding CT images. The most lesions on F-18 FDG PET/CT also demonstrated sclerotic change (20/23, 87%) with 3 osteolytic lesions. All metastatic lesions detected on bone scintigraphy and F-18 FDG PET/CT were found on F-18 fluoride PET/CT. In conclusion, F-18 fluoride PET/CT is superior in detecting osteosclerotic metastatic lesions than other tools. F-18 fluoride PET/CT might be useful method to evaluate osteosclerotic metastasis in breast cancer patients.","유방암 환자에서 골전이는 환자의 치료 및 예후에 큰 영향을 주는 요인으로, 이를 진단하는데 있어 전신 뼈 스캔이 주로 이용되고 있고 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography / computed tomography (F-18 FDG PET/CT) 역시 전이를 평가하는데 큰 역할을 하고 있다. 최근, 전신 뼈 스캔보다 더 민감하다고 알려진 F-18 fluoride PET/CT가 주목받고 있어, 본 연구에서는 골경화성 전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성을 알아보고자 하였다. 골경화성 전이가 동반된 유방암 환자 7명(여자 7명, 평균 연령 53 ± 11세)을 대상으로 전신 뼈 스캔, F-18 FDG PET/CT, F-18 fluoride PET/CT를 시행하였다. 육안 분석으로 각 검사에서 골전이 병소의 수를 기록하였으며, 이를 골격 구역(두개골, 척추, 흉부, 사지 장골, 골반뼈)에 따라 분류하여 구역별 병소 수를 비교하였다. PET/CT의 CT 영상을 이용하여 골용해성 또는 골경화성 병소로 구별하여 구역별 병소 수를 구였다. F-18 fluoride PET/CT에서는 총 88개, F-18 FDG PET/CT에서는 23개, 전신 뼈 스캔에서는 30개의 골전이 병소가 관찰되었다. F-18 fluoride PET/CT의 병소 대부분은 골경화성(84/88, 95%)이었으며, 4개 병소가 골용해성이었다. F-18 FDG PET/CT에서도 대부분 골경화성(20/23, 87%)이었으며, 3개의 골용해성 병소만 골용해성이었다. F-18 FDG PET/CT와 전신 뼈 스캔에서 관찰된 모든 병소는 F-18 fluoride PET/CT에서 관찰된 병소에 포함되었다. 이 결과는 F-18 fluoride PET/CT가 전신 뼈 스캔이나 F-18 FDG PET/CT보다 골경화성 골전이 병소를 진단하는데 민감하고 유용하다는 것을 나타낸다. 결론적으로, 골경화성 골전이가 의심되는 유방암 환자에서 F-18 fluoride PET/CT를 시행함으로써 골전이의 진단율을 높일 수 있을 것으로 기대된다.","국문요약 =ⅰ 차례 = ⅲ 그림차례 = ⅳ 표차례 = ⅴ Ⅰ. 서론 = 1 Ⅱ. 연구 대상 및 방법 = 3 A. 연구 대상 = 3 B. F-18 fluoride PET/CT 영상 획득 = 3 C. F-18 FDG PET/CT 영상 획득 = 4 D. 전신 뼈 스캔 영상 획득 = 4 E. 영상 분석과 비교 = 4 Ⅲ. 결과 = 6 Ⅳ. 고찰 = 8 Ⅴ. 결론 = 14 참고문헌 = 15 ABSTRACT = 19","Master"]},{"key":"dc:title","label":"Title","values":["골경화성 골전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성"]}]}],"canonical_facts":{"dc:contributor":["안, 영실","대학원 의학과","200724298","윤, 석호"],"dc:creator":["윤, 석호"],"dc:date":["2012-10-30T04:14:53Z","2012"],"dc:description":["Bone metastasis is an important factor for treatment and prognosis of breast cancer patients. Whole body bone scintigraphy can be used to evaluated bone metastases and also F-18 FDG PET/CT seems to exhibit high specificity and accuracy to detect skeletal metastases. However there is the limitation of F-18 FDG PET in assessing sclerotic bone metastasis because the lesions can be undetectable. Recent studies showed that F-18 fluoride PET/CT is more sensitive than bone scintigraphy to detect bone metastasese. The aim of this study is to evaluate usefulness of F-18 fluoride PET/CT in breast cancer patients with skeletal metastasis by comparing with bone scintigraphy and F-18 FDG PET/CT. Seven breast cancer patients with metastasis (7 females; mean age ± SD, 53 ± 11 y) underwent bone scan, F-18 FDG PET/CT and F-18 fluoride PET/CT. The images were evaluated with visual analysis based on consensus reading by 2 experienced nuclear medicine physicians. Lesion-based analysis was performed in various regions of the skeletons (skull, vertebral column, thoracic cage, long bones and pelvic bones). A total of 88 metastatic bone lesions were found on F-18 fluoride PET/CT, 30 lesions on bone scintigraphy and 23 lesions on F-18 FDG PET/CT. Most lesions on F-18 fluoride PET/CT had osteosclerotic change (84/88, 95%) with only 4 lesions showed osteolytic change on corresponding CT images. The most lesions on F-18 FDG PET/CT also demonstrated sclerotic change (20/23, 87%) with 3 osteolytic lesions. All metastatic lesions detected on bone scintigraphy and F-18 FDG PET/CT were found on F-18 fluoride PET/CT. In conclusion, F-18 fluoride PET/CT is superior in detecting osteosclerotic metastatic lesions than other tools. F-18 fluoride PET/CT might be useful method to evaluate osteosclerotic metastasis in breast cancer patients.","유방암 환자에서 골전이는 환자의 치료 및 예후에 큰 영향을 주는 요인으로, 이를 진단하는데 있어 전신 뼈 스캔이 주로 이용되고 있고 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography / computed tomography (F-18 FDG PET/CT) 역시 전이를 평가하는데 큰 역할을 하고 있다. 최근, 전신 뼈 스캔보다 더 민감하다고 알려진 F-18 fluoride PET/CT가 주목받고 있어, 본 연구에서는 골경화성 전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성을 알아보고자 하였다. 골경화성 전이가 동반된 유방암 환자 7명(여자 7명, 평균 연령 53 ± 11세)을 대상으로 전신 뼈 스캔, F-18 FDG PET/CT, F-18 fluoride PET/CT를 시행하였다. 육안 분석으로 각 검사에서 골전이 병소의 수를 기록하였으며, 이를 골격 구역(두개골, 척추, 흉부, 사지 장골, 골반뼈)에 따라 분류하여 구역별 병소 수를 비교하였다. PET/CT의 CT 영상을 이용하여 골용해성 또는 골경화성 병소로 구별하여 구역별 병소 수를 구였다. F-18 fluoride PET/CT에서는 총 88개, F-18 FDG PET/CT에서는 23개, 전신 뼈 스캔에서는 30개의 골전이 병소가 관찰되었다. F-18 fluoride PET/CT의 병소 대부분은 골경화성(84/88, 95%)이었으며, 4개 병소가 골용해성이었다. F-18 FDG PET/CT에서도 대부분 골경화성(20/23, 87%)이었으며, 3개의 골용해성 병소만 골용해성이었다. F-18 FDG PET/CT와 전신 뼈 스캔에서 관찰된 모든 병소는 F-18 fluoride PET/CT에서 관찰된 병소에 포함되었다. 이 결과는 F-18 fluoride PET/CT가 전신 뼈 스캔이나 F-18 FDG PET/CT보다 골경화성 골전이 병소를 진단하는데 민감하고 유용하다는 것을 나타낸다. 결론적으로, 골경화성 골전이가 의심되는 유방암 환자에서 F-18 fluoride PET/CT를 시행함으로써 골전이의 진단율을 높일 수 있을 것으로 기대된다.","국문요약 =ⅰ 차례 = ⅲ 그림차례 = ⅳ 표차례 = ⅴ Ⅰ. 서론 = 1 Ⅱ. 연구 대상 및 방법 = 3 A. 연구 대상 = 3 B. F-18 fluoride PET/CT 영상 획득 = 3 C. F-18 FDG PET/CT 영상 획득 = 4 D. 전신 뼈 스캔 영상 획득 = 4 E. 영상 분석과 비교 = 4 Ⅲ. 결과 = 6 Ⅳ. 고찰 = 8 Ⅴ. 결론 = 14 참고문헌 = 15 ABSTRACT = 19","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/7575","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012216","000000012216"],"dc:language":["ko"],"dc:subject":["F-18 fluoride","F-18 NaF","PET/CT","유방암","골전이"],"dc:title":["골경화성 골전이를 동반한 유방암 환자에서 F-18 fluoride PET/CT의 유용성"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:39Z"}