Characterization of Genes Specifically Expressed in Embryonic and Cancer Stem Cells

ES cells are derived from the ICM of blastocyst and have ability of self-renewal, unlimited proliferation and pluripotency that differentiate into cells of all three germ layers. The stem cell genes such as Pou5F1 (Oct4, Oct3/4), Sox2, Nanog, LIN28, KLF4, Myc (c-Myc) act alone and interact with each other for mainintaining the stem cell state. These genes have been already studied well. The emergence of new genes and the interaction with new genes can enhance research in the stem cell field. Some studied show that human embryonic stem cell genes are expressed in several cancer cells. Cancer cells or cancer stem cells have the similar characteristics. In order to understand the mechanism of the similar characteristics such as self-renewal, the development potential and the enhancement of proliferative ability, we find OR that is expressed in both stem cells and cancer cells using DDD. We make OR overexpressed in the human neural stem cells with the natural existence of OR expression accessory protein. This OR changed cell cycle indicating that OR acts as a regulatory member of cell cycle control system. This study is the clue to understand the basic mechanism of cell cycle control system of ES cells and cancer cells. Futhermore it can contribute in the field of ES cell and cancer cell research and therapy.

Author dc:creator

• 신, 정아

Contributors dc:contributor

• 이, 명애
• 대학원 의생명과학과
• 201024358

• Embryonic stem cell
• cancer stem cell
• self-renewal
• stemness
• cell cycle
• olfactry receptor

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012693
000000012693

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/7540