Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"stemness"”.
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Stemness status in differentiated and undifferentiated glioma cells
Undifferentiated cancer stem cells (CSCs) with their unique potential of self-renewal and multi-lineage differentiation fuel tumour growth and relapse. Efficacy of glioma therapy can be considerably improved if the target is focused towards successful identification and elimination of CSCs. The aim …
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Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer
<p>Ovarian cancer is the fifth leading cause of cancer death in women between the ages of 35 and 74. With 22 thousand new cases and 15 thousand deaths annually ovarian cancer is among the most deadly cancers with a death to incidence ratio of 68%. With 70% of cases High Grade Serous Ovarian …
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SMYD3: A PLAYER IN STEMNESS AND CHROMOSOME INSTABILITY IN TRIPLE NEGATIVE BREAST CANCER
La metilasi delle lisine SMYD3 risulta essere over espressa in diversi tipi di tumore, e legata alla transizione epitelio-mesenchimale (EMT) (1). Inoltre, le cellule staminali del cancro (CSCs) sono cellule iniziatrici del tumore importanti nella formazione di metastasi e correlate all’EMT (2). Il …
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RNA-Seq Reveals Transcriptomic Program Associated with Stemness in Taxane Resistant Prostate Cancer
… Results revealed a differential upregulation of stemness-associated genes in PCa cells selected for chemoresistance. In addition, chemoresistant cells formed robust stem cell prostaspheres compared to chemosensitive cells, and expressed other markers of cancer stem cells. Overall, these findings …
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Promoter-level transcriptome identifies stemness associated with relatively high proliferation in pancreatic cancer cells
付記する学位プログラム名: 充実した健康長寿社会を築く総合医療開発リーダー育成プログラム
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The Role of Glutamine and Mevalonate Pathway In Affecting The Stemness and Viability of Glioblastoma Stem Cells
<p><strong> </strong>Glioblastoma (GBM) remains the deadliest form of brain tumors. The poor prognosis of glioblastoma patients is associated with a high rate of relapse after therapy. It has been suggested that the presence of cancer stem cells, which are relatively resistant to radiation and …
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Molecular Interplay of Chromatin Remodeling Factor BRG1 and Transcription Factor STAT3 Regulates Stemness, Chemosensitivity and Tumorigenicity of Glioma Tumor Initiating Cells
<p>Glioblastoma Multiforme (GBM) is an aggressive brain tumor, characterized by high cellular heterogeneity, is refractory to treatment and has dismal prognosis. These characteristics of GBM have suggested the presence of stem-like cells that have the ability to initiate and maintain tumors of a …
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Treating MTAP-Deficient Brain Tumors with Purine Synthesis Inhibition
… a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via …
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Effects of Trimethylamine N-Oxide on Mouse Embryonic Stem Cell Properties
… conditions, mESC viability, proliferation, and stemness were analyzed. mESC properties were not negatively impacted under long-term, low-dose TMAO treatment; however, short-term, high-dose treatment resulted in significant reduction of mESC viability and proliferation. Additionally, mESC …
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Transcriptional regulators in stem cell biology
… the functions of transcriptional regulators of stemness may differ in normal and transformed cells. In this thesis, I describe two transcriptional regulators of stemness and their deployment in adult stem cells and cancer. The first study focuses on the epigenetic regulator B-cell-specific …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… ID2 promoted DCIS formation by enhancing cancer stemness of premalignant cells. On the other hand, we compared the DCIS.com and invasive breast cancer cell line, MCF10CA, and identified INHBA and GJB2 as novel regulators of aggressive phenotype. These 2 genes regulated migration, colonization and …
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The Functions of Setd5 and Mir-221 In Embryonic Stem Cell Differentiation
… by the <em>miR-221</em> gene, are new anti-stemness miRNAs whose expression levels in mouse ESCs are directly repressed by the epigenetic modifier and pluripotent factor PRMT7. Notably, both miR-221-3p and miR-221-5p can target the 3’ untranslated regions of the major pluripotent factors …
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Acetyl-CoA metabolism and human trophoblast differentiation
… ACLY is essential for maintaining trophoblast stemness by providing a localised supply of acetyl-CoA for histone acetylation, thus leading to a transcriptionally permissive state associated with trophoblast self-renewal. The role of cell culture medium on trophoblast behaviour was initially …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
… by chronic castration or overexpression of the stemness factor NANOG. Therefore, my overarching hypothesis is that PSA-/lo cells possess intrinsic molecular and epigenetic features that regulate their aggressiveness and stemness and contribute to tumor progression and therapy resistance, and …
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Targeting the intestinal stem cell niche through energy and metabolism signaling, for colorectal cancer chemoprevention using aspirin and metformin
… evidence indicates that overnutrition increases ‘stemness’: the ability of intestinal stem cells to self-renew or differentiate. The mechanistic target of rapamycin (mTOR) pathway, a central metabolic regulator, is elevated in CRC and modulates stem cell response to nutrients. Therefore, …
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HECAT5 regulates cell proliferation via interaction with M3R in cell type-specific manner
… To investigate the mechanism regulating stemness, especially cell cycle of ES cells, our previous study identified HECAT5 which is co-expressed in both ES and cancer cells, but not normal tissues by using Digital Differential Display (DDD). Overexpression of HECAT5 promotes self-renewal …
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Investigating The Role Of Chaperone-Mediated Autophagy In Glioma Stem Cells
… therapy. However, how GSCs maintain their stemness remains unclear. Here, we show that during the differentiation of glioma stem cells, the activity of chaperone-mediated autophagy (CMA), a form of autophagy that selectively targets cytoplasmic proteins for lysosomal degradation, is …
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Stem cell matrix and cartilage regeneration
… microenvironment that can maintain or enhance stemness is urgently needed for facilitating large-scale tissue engineering. To facilitate ex vivo expansion, the conventional methods for stem cell expansion were extensively investigated. We first compared the influence of low- and high-seeding …
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