Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"cell cycle control"”.
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The role of anchorage in cell cycle control
Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint mechanisms. Transformed cells alleviate these …
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Cell Cycle Control by Cyclin-CDKS in Chlamydomonas Reinhardtii
<p>The cell cycle consists of a series of events, including replication and segregation of the genome, that occurs in order to ensure successful reproduction of cells. In fungi and animals, this process is carefully regulated by a set of protein complexes with alternating, oscillating activity. A …
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Cell cycle control of aspartate transcarbamylase levels in Chlorella sorokiniana
… or multiple passages through a French pressure cell. The loss of sensitivity to inhibition may be due to breakdown of the enzyme into subunits or breakdown of a multienzyme complex of pyrimidine enzymes. An assay for activity of carbamyl-P synthetase (E. C. 2.7.2.5), a suspected component of the …
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Mathematical Model of the Cell Cycle Control and Asymmetry Development in Caulobacter crescentus
… crescentus goes through a classic dimorphic cell division cycle to adapt to the stringent environment and reduce intraspecific competition. Caulobacter mother cell gives rise to two progenies with distinct morphology - a motile swarmer cell equipped with a flagellum and a sessile stalked cell …
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The role of E2F·pocket protein repressive complexes in cell cycle control and differentiation
… Go and recruiting in the pocket proteins. As cells begin cycling, E2F4 and E2F5 are replaced at promoters by members of the activating E2Fs subgroup. Loss of either E2F4 or E2F5 does not result in cell cycle defects but instead lead to the abnormal development of specific tissues. The lack of …
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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
… interactions to accomplish critical functions of cellular metabolism. Over the past 2 decades, much attention has been focused on roles of LA in maintenance of nuclear structural integrity. Only since the late 1990s have scientists discovered the devastating effects of LA gene (LMNA) mutations, as …
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Polyploidy in Saccharomyces cerevisiae leads to the loss of cell cycle control in stationary phase
… of the growth patterns of haploid and tetraploid cells during stationary phase reveals that tetraploids are defective for growth arrest during nutrient deprivation.
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Cell cycle control governing built-in asymmetry underlying the spindle pole body duplication cycle in Saccharomyces cerevisiae
Self-renewing stem cell divisions typically couple the polarised orientation of the mitotic spindle with an invariant age-dependent pattern of centrosome inheritance. Self- renewal supports tissue homeostasis by providing, in a balanced manner, one daughter cell retaining stemness and another …
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Genome-wide CRISPR Screening in FBXW7-mutant Cells Uncovers Multiple Druggable Synthetic Lethal Interactions Involving Cell Cycle Control
… broadly target actively dividing cells, with both healthy and cancerous cells being damaged, causing toxic side effects. Personalized oncology aims to selectively target cancerous cells based on their mutational status, minimizing toxic and life-altering side effects, while …
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The Animal-fungi Hybrid Cell Cycle of the Zoosporic Fungus Spizellomyces punctatus - a New Model to Understand Evolution of Eukaryotic Cell Cycle Control
<p>The cell cycle is arguably one of the most conserved regulatory networks within Eukaryotes. Despite the animals and fungi are sibling “kingdoms” within the Opisthokont supergroup, the core transcription factors that control commitment to cell division (E2F and SBF, respectively) and their …
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Exploration of Cell Cycle-Specific Essential Gene Functions in the Microbial Plant Chlamydomonas Reinhardtii
<p>The cell cycle encompasses all the steps required for cell proliferation, and is normally tightly coupled to growth and division in all organisms. Much research has resulted in a well-supported model of eukaryotic cell cycle control. However, since most of this research has been carried out in …
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Characterization of Genes Specifically Expressed in Embryonic and Cancer Stem Cells
ES cells are derived from the ICM of blastocyst and have ability of self-renewal, unlimited proliferation and pluripotency that differentiate into cells of all three germ layers. The stem cell genes such as Pou5F1 (Oct4, Oct3/4), Sox2, Nanog, LIN28, KLF4, Myc (c-Myc) act alone and interact with …
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Electron microscopic studies of mitotic chromosomes in yeast
… to determine many of the components involved in cell processes such as cell cycle control and secretion. One of the unresolved problems in yeast cell biology is whether or not the chromosomes of the yeast, Saccharomyces cerevisiae, condense during mitosis and, if they do, to what extent they are …
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Role of retinoblastoma protein in the development of liver cancer
Hepatocellular carcinoma is the sixth most common cancer worldwide with a diverse aetiology. Dysregulation of the Rb pathway can occur in as high as 92% of liver cancers implicating Rb as an important factor in the progression of the disease. The impact Rb loss has on the development of liver …
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STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control
… coordinates DNA damage response in non-immune cells and thereby contributes to cell-intrinsic prevention of oncogenesis is not known. The present work uncovers a novel role and identifies STING as an epithelial, interferon-independent genome-integrity checkpoint that couples DNA damage …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
… most human tumors resulting in deregulation of cell cycle control through the inappropriate release of E2Fs. E2F1, E2F2, and E2F3 are members of the "activating E2F" subfamily that is important for the transcriptional activation of target genes involved in DNA replication and cell cycle control. …
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The function of E2F6 in the Polycomb complex
The E2F family of transcription factors are known cell cycle regulators that function at the G1/S transition. Unlike other E2Fs, E2F6 does not activate transcription and is not regulated by pocket protein binding. Instead, this protein appears to repress transcription through the recruitment of the …
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Exploring Kinases of Metabolism and Signaling in the Malaria Parasite Plasmodium
… they are essential regulators in signaling, cell cycle control, and metabolism. Additionally, kinases play important roles in disease states, including cancer, heart disease, and neurodegenerative disorders. This has encouraged the work described here, which focuses on characterizing the …
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Crosstalk between E2F3 and p19ARF/p53 in the regulation of cell cycle progression and tumorigenesis
… identified as a critical component of the cellular machinery responsible for promoting cell cycle progression that is co-opted during transformation and tumorigenesis. Classic E2F target genes have functions required for S-phase entry and progression. However, the role of E2F has expanded …
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