Numerical simulation of platelet adhesion, activation and aggregation : application to Taylor-Couette systems

Heart attack and stroke are among the leading causes of death in industrial nations but the number of candidates needing a transplant exceeds the number of transplants performed. Due to this chronic shortage, blood pumps are needed to deliver appropriate hydraulic performance while maintaining physiological flow conditions. Because all known artificial materials are considered to be thrombogenic to some extent it is necessary to investigate the interaction of flow and material in complex geometries to optimize modern blood pumps and other artificial organs. As human blood is a precious fluid, designers of rotational blood pumps desire reliable predictive thrombosis models to optimize the physiological compatibility of their devices. In this thesis, the initial development stage of a model for platelet adhesion, activation and aggregation is described. Model equations and methods for their numerical solution are presented. The Taylor-Couette system, as a well investigated rotational device, is simulated as a test case to estimate model parameters and to explore the predictive accuracy of the model.

Grantor dc:publisher

Publikationsserver d. RWTH Aachen Univ.

Year dc:date

2008

Author dc:creator

• Waluga, Christian

Contributors dc:contributor

• Behbahani, Mehdi

• info:eu-repo/classification/ddc/620
• Thrombose
• Finite-Elemente-Methode
• Nichtlineare Finite-Elemente-Methode
• Thrombozyt
• Adhäsion
• Aggregation
• Numerische Strömungssimulation
• Advektion-Diffusionsgleichung
• Blutpumpe
• Taylor-Couette-Strömung
• Ingenieurwissenschaften
• thrombosis
• advection-diffusion equation
• Taylor-Couette system
• computational fluid dynamics
• finite-element method

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112312%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A48716