Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 235 for “"thrombosis"”.
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Thrombosis in Children
… to determine what children are affected by thrombosis; to discern any gender or age differences related to thrombosis; to identify prothrombotic risk factors; to ascertain whether autoantibodies against coagulation proteins constitute a risk factor for childhood thrombosis; to study girls …
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Polyphosphate modulates hemostasis, thrombosis, and inflammation
… studies also implicate polyP in contributing to thrombosis and consumptive coagulopathies accompanying bacterial sepsis. PolyP polymer lengths are known to vary substantially among different organisms and cell types, with shorter polymers secreted by human platelets and much longer polymers …
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Mechanisms and Diagnosis of Thrombosis in PCOS
… and has been linked to increased risk for thrombosis, a leading cause of morbidity and mortality worldwide. However, the overall prevalence of thrombotic events and the mechanisms of thrombosis in PCOS are unknown. Limitations in our clinical assays have hindered research and patient care, …
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Effects of air pollution on vascular thrombosis
… of this work were to develop an in vivo model of thrombosis, to determine whether exposure to DEP did alter clotting. Initial attempts to develop the Folts’ model (which stimulates thrombus formation via arterial stenosis and mechanical injury), first in male C57/Bl6 mice and later in male Wistar …
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Role of Monocytes and Neutrophils in Thrombosis
Arterial thrombosis is the major trigger of myocardial infarction and ischaemic stroke. Although platelets are the most abundant cell in arterial thrombi, platelets interact closely with leukocytes such as monocytes and neutrophils and modify their activity. This thesis aims to identify novel …
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Non-invasive early diagnosis of deep vein thrombosis
Deep Vein Thrombosis (DVT) is a blood clot that forms in deep veins which commonly occur in lower limb or thigh. The blood clot blocks deep vein and can travel to lung and block pulmonary arteries. This condition will cause fatal Pulmonary Embolism (PE). DVT can be diagnosed using non-invasive …
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The incidence and prevention of Postoperative Venous Thrombosis
… few years a very high incidence of deep vein thrombosis has been reported in the literature. Venous thrombosis and its sequel, pulmonary embolus account for 12. 5% of all postoperative deaths and is the single greatest threat to recovery after surgical operations. This study was undertaken to …
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Thrombotic fingerprints for the enhanced prediction of thrombosis
Controlled thrombosis initiates and regulates tissue repair and remodeling in the vessel wall. Processes from heart attack to stroke, and deep vein thrombosis to pulmonary embolism, are all derived from unrestricted clotting. The frustrating aspects of these diseases lie not only in the difficulty …
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PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR IN BLEEDING AND THROMBOSIS
… different thrombotic disorders such as arterial thrombosis, ischemic stroke and venous thromboembolisms. The dual role of VWF in both bleeding and thrombosis, with a focus on VWD and deep vein thrombosis (DVT), are discussed in this thesis. In the first part, we described the approach used to …
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A Mechano-Chemical Computational model of Deep Vein Thrombosis
Deep Vein Thrombosis (DVT) is the formation of a blood clot in a vein, usually in the body's lower extremities. If untreated, DVT can lead to pulmonary embolism (PE), heart attack and/or stroke, which can be fatal. According to literature, DVT affects 0.2% of people in developed countries and about …
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Pulsatile Flow in Computational Modelling of Thrombosis in Cerebral Aneurysms
… of a growing number of computational models of thrombosis of cerebral aneurysms designed with consideration towards clinical use and research. Their model, amongst many others, utilizes computationally inexpensive steady flow conditions. However, pulsatile flow better characterizes blood flow …
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The Development of a Computational Model of Thrombosis in Hemodialysis Catheters
… of a three-dimensional computational model of thrombosis in three hemodialysis catheters designs was undertaken. Development of the computer model was beset with challenges associated with limitations in both software and hardware, but those challenges were ultimately overcome as both software …
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The development of an in vitro model of coronary lesion thrombosis
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
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Computational and biological studies of mechanical prophylaxis against deep venous thrombosis
Deep vein thrombosis (DVT) of the lower extremity and induced pulmonary embolism are common complications resulting from prolonged periods of bed-rest or immobilization of the limbs. One of the most effective methods of prophylaxis against DVT is external pneumatic compression (EPC). In spite of …
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STUDYING THE INTERACTION OF CANCER AND THROMBOSIS THERAPEUTICS WITH PROTEIN AND DNA
In my dissertation research I have used atomic force microscopy (AFM), simulations and molecular biology to investigate different classes of therapeutics. Many cancer drugs bind to DNA and inhibit replication. We have AFM and simulations, based on the worm-like chain model (WLC), to study DNA …
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A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… collagen. Developing new microfluidic models of thrombosis may lead to a better understanding of the mechanisms involved and produce diagnostic tests for thrombotic diseases.
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Venous Thrombosis: Formation, Evolution And Resolution Imaging Using Non-Invasive MRI Techniques
Deep venous thrombosis (DVT) remains a major health problem. Although thrombolytic therapies are effective in recanalising the veins, restoring blood flow, preventing pulmonary embolism and post-thrombotic complications, there is still no consensus on the selection criteria for this invasive …
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Risk factors for deep vein thrombosis in a South African public hospital
The evidence suggests an association between HIV, TB and DVT. There are no studies of this link in the Southern African setting, where the incidence of both of these conditions (HIV and TB) is high. We therefore undertook a study to define the incidence of HIV and TB in patients with confirmed DVT …
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A Novel Manually Operated Compression Device for the Prevention of Deep Vein Thrombosis
Deep Vein Thrombosis, a potentially fatal event, occurs when a blood clot forms within the deep veins of the body. This most frequently manifests in the lower extremities. The goal of this research was to build an inexpensive device that could apply therapeutic compressive pressure to the lower leg …
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Visualisation on blood flow mechanism of vein in deep vein thrombosis (DVT) study
… condition at the earliest stage of Deep Vein Thrombosis (DVT), this study aims to assess the velocity and vorticity at the valve region using the Computational Fluid Dynamics (CFD) method. The velocity ofblood and the size of valve orifice are considered important parameters in designing the …
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