Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"interferon alpha"”.
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Beta Cell Heterogeneity in the Acute Interferon Alpha Response
… system produces various cytokines, including interferon alpha (IFN-α), which has long been implicated in T1D pathogenesis. Our study explores how IFN-α influences human β-cell function, particularly its role in reactive oxygen species (ROS) production—signaling molecules essential for normal …
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Cognitive, biological and psychosocial factors predicting interferon-alpha-induced depression
Interferon-alpha (IFN-α) therapy for chronic hepatitis C virus (HCV) infection is associated with the development of depression and other neuropsychiatric adverse effects. However, well-defined predictors of this depression are still lacking. Several interlinked biological systems as well as …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
The interferon alpha receptor (IFNAR) and T-cell receptor (TCR) are expressed upon the T-cell surface. The dimeric Class I interferon receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative …
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
… characteristic features of ARFs: induction by interferon (IFN), and downregulation by viral infection. Proteomics was used to investigate cell surface changes in primary monocytes and CD4+ T-cells upon stimulation with IFNα, across five donors. The cell surface proteomes were characterised, and …
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Evaluation kognitiver Störungen bei Patienten mit chronischer Hepatitis C unter Therapie mit Interferon-alpha und Ribavirin
… mit chronischer Hepatitis C in Behandlung mit Interferon-a als Monotherapie oder in Kombination mit dem Guaninanalogon Ribavirin wurden auf häufig geschilderte neurotoxische Nebenwirkungen, insbesondere kognitive Störungen sowie die Entwicklung von Symptomen eines depressiven Syndromes objektiv …
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Die Bedeutung von Interferon alpha und Interferon gamma auf den Verlauf der Marekschen Krankheit beim Haushuhn
… between host and virus needs to be expanded. Interferons are cytokines with antiviral activity. On the basis of their structural and functional features they can be divided into type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) interferons. Type I plays an important role during the early …
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Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
Previous studies demonstrate that interferon alpha (IFN-α) promotes human T helper 1 memory development by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta …
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Η συμβολή της ραδιοανοσολογικής μεθόδου στη μελέτη της φαρμακοκινητικής της ιντερφερόνης σε ασθενείς με νεοπλάσματα
The use of interferon alpha is currently established for the treatment of certain neoplastic diseases and among them for the management of malignant melanoma. Considering the extremely high cost of this product and the existing relationship between the therapeutical results and the levels of the …
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Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение
… Fibrosis regression was observed after interferon-alpha and ribavirin therapy in 50 percent of the cases, with viral eradication and fibrosis progression in those who did not respond to treatment.
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Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… conditions in the CNS. Tumor necrosis factor-$\alpha$ (TNF) is an inflammatory cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating neuronal injury. TNF can protect neurons from excitotoxic and metabolic …
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Development of novel imaging technology to study cell signalling
… The nanopipette was also used to locally deliver interferon β onto mouse embryonic fibroblasts, to trigger the interaction between the interferon alpha and the beta receptor subunit 1 and the interferon alpha and beta receptor subunit 2. Lastly, in order to improve the light sheet imaging …
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Local immunopotentiation of the bladder in response to BCG immunotherapy
… and schedule may be tolerogenic.The addition of interferon alpha (IFNI?) to BCG induces more interferon gamma production, a cytokine known to increase the TH1 cellular immune response and anti-tumour efficacy. IFNI? with low dose BCG has significantly less toxicity and superior efficacy to …
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Dendritic cell maturation and activation via RNA/DNA danger signals : co-delivery of protein antigen with siRNA or CpG DNA
… immunosorbent assays for interleukin 12 and interferon-[alpha], respectively, that DCs were activated by CpG oligonucleotide- and siRNA-functionalized nanoparticles [approx.]10-fold more potently than by soluble CpG or siRNA ligands.
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Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
… ability to act as a substrate for insulin and interferon alpha (IFNalpha) receptors. PI 3-kinase is shown to associate with a wortmannin insensitive 76 kDa serine phosphoprotein (pp76) distinct from the p85 subunit of PI 3-kinase. pp76 is phosphorylated by an okadaic acid sensitive, PI 3-kinase …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… agents all-trans retinoic acid and interferon alpha up-regulate CysLT2R expression in colorectal cancer cells; 4) LTC4, a ligand for CysLT2R, inhibits migration of colorectal cancer cells; 5) Intestinal epithelial and colorectal cancer cells express enzymes and receptors of the …
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The Changing Face of Craniopharyngioma Treatment in Young Children and its Challenges at a Single Centre in a Developing World Context
… from Yttrium (1) to Bleomycin (6) to Interferon Alpha (6). Radiotherapy was given in 30 patients, median dose 54Gy. Final Wen functional outcome was 21,8% Class I, 32% Class II and 46% Class III. There were no early deaths in the series but 5 patients died more than 6 years after …
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Intranasal Immunization of Pigs with Porcine Reproductive and Respiratory Syndrome Virus like Particles Plus 2’, 3’ –cGamp Vaccigrade™ Adjuvant Exacerbates Viremia After Virus Challenge
… bring more immune cells for the virus to target. Interferon-alpha concentrations were also higher in the VLPs with adjuvant group, but there was only a slight increase in IL-10 and interferon-gamma. The VLPs with adjuvant group showed a significant increase in VLP specific IgG and IgA at 7 DPC …
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Protection from HCV infection – Identification of mechanisms of resistance to HCV infection in exposed uninfected injection drug users.
… but has also identified a marked upregulation of interferon alpha production to low dose viral RNA in EU cases utilising ELISA assay. In conclusion, this thesis reports data that identifies a number of new findings that provide insight into mechanisms of resistance to HCV infection. My findings …
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… regulation and more recently, modulation of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection …
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ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION
… therapies (World Health Organization 2025). Interferon-alpha (IFN- α), including its pegylated forms, is approved for CHB treatment, but its efficacy is limited to a small subset of patients, and its mechanism of action remains poorly understood. Indeed, interferon therapy can activate …
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