Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 239 for “"co-expression"”.
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Integrative transcriptomic approaches to analyzing plant co-expression networks
It is well documented that transcriptionally coordinated genes tend to be functionally related, and that such relationships may be conserved across different species, and even kingdoms. (Ihmels et al., 2004). Such relationships was initially utilized to reveal functional gene modules in yeast and …
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CD21 and CD24 Co-expression: A Translational Model between Mouse and Human
… these diseases result in variable clinical outcomes. Thus, a need exists to better understand the dynamics of human B cell production and function. The mouse model has provided a foundation for understanding the mechanisms involved in human B cell development and autoimmune disease. However, …
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Co-expression de la pro-protéine convertase SPC3 et du précurseur neuroendocrinien proSAAS
Les pro-protéines convertases de type subtilisine (SPCs) sont une famille d'enzymes de type sérine protéinases. Les convertases sont impliquées dans la maturation de diverses hormones et protéines sécrétées via leur clivage en C-terminal d'une paire de résidus d'acides aminés basiques de type …
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Using co-expression to redefine functional gene sets for gene set enrichment analysis
… gene sets related to a biological function often contain genes that are not tightly co-regulated transcriptionally. which obscures the evidence of coordinated differential expression of these gene sets in relevant experiments. To address this problem, we explored strategies to refine the manually …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
… leads to scarring, cell hypertrophy, and loss of contractility in the left ventricle. Driving endogenous cardiomyocyte proliferation is a promising avenue for heart remuscularisation in the context of ischaemic damage. Overexpression of Ccnt1 creates a permissive molecular environment for …
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Effects of co-expression of chaperone combinations on production of soluble plasmodial protein PfAdoMetDC in E. coli
… of the malaria parasite. They are critical components of cell growth and division, particularly in rapidly proliferating cells that include cancerous cells and numerous parasites. Hence, PfAdoMetDC protein is regarded as an ideal drug target for malaria. Even though E. coli is the most …
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Identification And Characterization Of The Major Gene Ma And Its Associated Co-Expression Gene Networks Regulating Apple Fruit Acidity
Apple fruit acidity which considerably affects fruit taste and flavor is primarily determined by malate concentrations. Previous studies reported that apple fruit acidity was predominantly controlled by the major QTL Ma. To better understand apple fruit acidity, this study attempts to identify and …
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Comparative transcriptomics and co-expression networks reveal tissue- and genotype-specific responses of QDTYS to reproductive-stage drought stress in rice (Oryza sativa l.)
… rice, drought remains a major environmental constraint to rice production. While a few gene-expression profiling studies in rice in response to drought at the reproductive stage have been conducted, our knowledge of biological mechanisms in this respect is limited. Analysis tends to be …
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Untersuchungen zur Identifikation von Interaktionspartnern der Nemo-like-Kinase, Nlk
… konnte gezeigt werden, dass die Co-Expression von Gal-Nlk mit jedem der VP16-Fusionsproteine in einer geringen Transkriptionsaktivierung resultiert. Dies deutet darauf hin, dass Nlk außer mit β-Catenin und LEF-1 auch mit Id2 bzw. Id3 interagieren könnte. Allerdings wird schon in …
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Understanding factors that affect gene co-regulation patterns
… with behavior disorders and immune system can be complex and challenging. Gene expression and network analysis can help to elucidate the main molecules and pathways that influence complex traits. The goal of these studies is to understand factors that affect gene co-regulation patterns related to …
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Understanding compound-induced histopathology in rat liver using gene expression network methods
Current drug discovery is a lengthy and costly pipeline; it takes between twelve and fifteen years and costs $1-2 billion (USD). As such, any compound failures represent a sunk cost – exacerbated if such failures occur later in the pipeline. Compound and drug induced liver injury is a significant …
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THE HOST-PATHOGEN INTERACTOME AND REGULATORY NETWORKS OF ASPERGILLUS FLAVUS PATHOGENESSIS OF ZEA MAYS: RESISTANCE IN MAIZE TO ASPERGILLUS EAR ROT AND TO AFLATOXIN ACCUMULATION
… between a pathogen and its host is a complex series of events that occurs at the molecular level and is controlled by transcriptional and protein interactions. To facilitate the understanding of these mechanisms in Aspergillus flavus and Zea mays, three approaches were taken: 1) the …
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Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment
Bioinformatics is a subfield in computational science that is principally focused on developing methods and performing data analytics in the areas of proteomics and genomics. In this thesis I draw a link between proteomics and genomics by focusing on the regulation patterns of glycosyltransferase …
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Bioproduction Optimization and Characterization of Hyaluronic Acid in Escherichia coli and Nicotiana benthamiana
… strongly dependent on molecular weight. Conventional production methods, including animal tissue extraction and Streptococcus fermentation, yield high-molecular weight HA and require additional processing to obtain low-molecular weight polymers. Additionally, these methods carry ethical …
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Proneural Genes in Neocortical Development
The timing of neocortical development is regulated by both intrinsic proneural genes Neurog2 and Ascl1, and extrinsic signals. However, how these intrinsic factors and extrinsic signals coordinatedly control neural cell fate decisions was not well understood at the start of my studies. Neurog2 and …
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Calcium Channel Gamma(6) Subunits Are Unique Modulators of Low Voltage-Activated Calcium Current
The calcium channel gamma (gamma) subunit family consists of eight members whose functions include modulation of high voltage-activated (HVA) calcium currents in skeletal muscle and neurons, and regulation of AMPA receptor targeting. Cardiac myocytes express three gamma subunits, gamma 4, gamma6 …
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
… 50% EGFRvIII-positive and -negative tumors pre-conditioned with non-lymphodepleting irradiation. IL7 and IL7 Flt3L CAR T cells increased intratumoral CD8 CAR T cell populations seven days after treatment. IL7 co-expression with Flt3L increased conventional dendritic cells (cDCs) as well as the …
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Classification of Neuronal Nicotinic Acetylcholine Receptors in Rat CA1 Hippocampal Interneuron Subpopulations Defined by Calcium-Binding Protein mRNA Expression
… the single-cell relative quantitative mRNA expression of three Calcium-binding proteins (CaBPs; calbindin, calretinin, parvalbumin) and eight nicotinic acetylcholine receptor (nAChR) subunits (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens …
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Investigating Extreme Lifestyles Through Mangrove Transcriptomics
… phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), and dihydroflavonol reductase (DFR) gene families in R. mangle , which are at major regulatpry points in the phenylpropanoid pathway. I have identified one DFR, two CHS, and ten PAL genes in R. mangle . Differential expression …
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