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Showing 1 to 20 of 59 for “"VLP"”.

  1. Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric adjuvant-free VLP vaccines targeting oncoviruses

    Zhang, Bingyang2021

    … Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric adjuvant-free VLP vaccines targeting oncoviruses. Two chimeric HBc VLP-based vaccines presenting Epstein–Barr virus nuclear antigen 1 (EBNA1) epitope (short and non-structural epitope) and Hepatitis C …

    adelaide Repository record

  2. Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice

    Pillay, SirikaDepartment of Molecular and Cell Biology2008

    … virus. One such approach is the use of HIV-1 Gag VLPs as vaccine candidates. In this study, the production of two chimaeric (Gag VLP vaccine candidates (GagRT and GagTN) was optimized in insect cells, and their ability to enhance a murine immune response in a DNA prime-VLP boost vaccine strategy …

    cape-town Repository record

  3. A study of the immune response to human papillomavirus types causing cervical cancer

    Marais, Dianne JeanDivision of Medical Microbiology2000

    … P = 0.039) and HPV-16 virus-like particles (VLP-16, P = 0.002). This association was found to be age-dependant in women with CIN, with a higher antibody seropositivity rate to E2-16 noted in women over 40 years and a lower antibody seropositivity rate to VLP-16 found in the older women. This …

    cape-town Repository record

  4. ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS

    V. RainoneUniversità degli Studi di Milano2010

    … mucosal lamina propria. Virus-like particles (VLPs) are a novel vaccine approach based on non-pathogenic particles that mimic the structure of authentic virus particles. Immunogenicity of vaccines can be improved by the use of chemokine molecular adjuvants. Here we propose experimental …

    milano Repository record

  5. Investigating Genetically Engineered Virus-Like Particles Using Molecular Dynamics Simulations for Enhanced Vaccine Development

    Luo, Hong2025

    Virus-like particles (VLPs) mimic the structure of viruses without containing viral genetic material, making them safe and highly immunogenic platforms for vaccine development. Genetic modifications can expand the use of VLPs, such as the insertion of antigens to target various diseases. However, …

    adelaide Repository record

  6. An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines

    Singh, VedanthaDivision of Virology2013

    … or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on HIV-1 subtype C are able to successfully induce vaccine specific responses in Chacma baboons. The aim of the current study was to characterise the T cell memory phenotype distribution in peripheral mononuclear cells (PBMCs) …

    cape-town Repository record

  7. Biochemical Investigation of the Intracellular Trafficking of Non-Viral and Hybrid Gene Therapy Vectors

    Drake, David MichaelUniversity of Illinois at Urbana-Champaign2015

    … thereby estimating endosomal escape of VLP. MLV were observed to achieve reverse transcription rapidly, with more than half of infecting viruses being reverse transcribed within 8 hours. PEI:VLP were delayed approximately 4 hours (relative to viruses) in having their RNA reverse …

    uiuc Repository record

  8. Production of plant-expressed virus-like particle vaccines against infectious bronchitis coronavirus and vaccine efficacy in chickens

    University of Pretoria2022

    … industry. In this study, virus-like particles (VLPs) were produced using Agrobacteriummediated transient protein expression in Nicotiana benthamiana plants as potential vaccines against IBV. Modifying the full-length IBV Spike (S) protein resulted in high levels of VLPs resembling native IBV …

    pretoria Repository record

  9. "Molecular Analysis of Virulence Factors Unique to Leptopilina heterotoma-a Parasitic Wasp of Drosophila spp."

    Dziedzic, Noelle2018

    … venom proteins and virus-like particles (VLPs) into developing fly larvae. VLPs are endocytosed by plasmatocytes, a macrophage-like blood cell that is the most abundant hemocyte present in the circulating hemolymph. Once internalized, VLPs destroy plasmatocytes by programmed cell death. To …

    cuny Repository record

  10. The Development and Assessment of Immune Responses in Plasmid DNA, VSV-Vectored, and Virus-Like Particle HIV Vaccinations in Murine Models

    Qi, LeiThe University of Western Ontario2024

    … vaccine vectors: VSV, virus-like particle (VLP), and DNA; 2) immunogens: transmitted founder strain A74 N425 wild type and N425K mutant; and 3) conformational changes: vaccines with or without CD4 mimetic interaction, to identify the best vaccine candidate. We also investigated the …

    uwo Repository record

  11. Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles

    Halsey, Richard JamesDepartment of Molecular and Cell Biology2006

    … C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA polyepitope DNA vaccine pTHr.HIVA. A range of …

    cape-town Repository record

  12. Developing SINrep5 as a Viral Vector Platform to Test SARS-CoV-2 Vaccine Candidates

    Chen, MichelleGraduate Studies2023

    … for protein expression and Virus-Like Particles (VLP) production. Techniques to purify, concentrate, and quantify VLP titres were also optimized. C57Bl/6 Mice were received VLP vaccines and humoral immunity was assessed. An efficient cloning system was developed for the SINrep5 mammalian …

    calgary Repository record

  13. Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)

    Lu, YiVirginia Tech2020

    … forms an icosahedral capsid virus-like particle (VLP) that has 240 repeats in a single assembled particle. By inserting different epitope antigens from these porcine pathogens into the particle, we can achieve repetitive antigen presentation to the host's immune system by taking advantage of the …

    vt Repository record

  14. Investigation of particulate Bluetongue virus vaccines made in plants

    Gwynn, AbigailDepartment of Molecular and Cell Biology2023

    … strategies is that of the virus-like particle (VLP). BTV VLPs comprise four structural proteins, namely VP2, VP3, VP5 and VP7. VP2 is highly immunogenic and is responsible for eliciting neutralising antibodies against the virus. Although a number of different BTV VLPs have been produced in …

    cape-town Repository record

  15. Analysis, Optimization and Application of AAV Capsid Assembly using Escherichia coli

    Le, Dinh ToUniversität Bielefeld

    … AAV empty capsids as virus-like particles (VLP) produced in mammalian cells have raised increasing interest for vaccine development and drug delivery. This thesis established a new approach to produce AAV VLPs using E. coli and in vitro capsid formation. The use of these AAV VLPs for vaccine …

    bielefeld Repository record

  16. Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model

    Ramesh, Ashwin KumarVirginia Tech2020

    … on genetically engineered virus-like particles (VLPs) comprised of the major HuNoV capsid protein VP1. We tested the immunogenicity of a novel tetravalent VLP vaccine containing 4 major HuNoV genotypes (GI.1, GII.3, GII.4 and GII.17) using Gn pigs and evaluated its protective efficacy when …

    vt Repository record

  17. Distribution of Free Marine Viruses of Lower Chesapeake Bay and Their Effects on Life-History Parameters of the Estuarine Copepod <i>Acartia tonsa</i> Dana

    Drake, Lisa A.2019

    … the distribution of virus-like particles (VLPs) and bacteria in the lower Chesapeake Bay, vertical profiles of VLPs and bacteria were determined through the water column and 15-25 cm into the sediment at five stations. VLPs were about ten times more abundant in sediment pore water (3.7 x …

    odu Repository record

  18. Virus-like particles as a vaccine against porcine reproductive and respiratory syndrome virus

    Venkatesh Murthy, Ambika MosaleVirginia Tech2013

    … PRRS universal vaccines. Virus like particles (VLPs) based vaccines are gaining increasing acceptance compared to subunit vaccines, as they present the antigens in more veritable conformation and are even readily recognized by the immune system. Hepatitis B virus (HBV) core antigen (HBcAg) is …

    vt Repository record

  19. Development of plant-produced African horse sickness vaccines

    Dennis, Susan JenniferDepartment of Molecular and Cell Biology2019

    … for the production of virus-like particles (VLPs), which are excellent vaccine candidates, as they do not contain virus genetic material and are DIVA compliant. A vaccine alternative to the currently used live vaccine necessarily needs to provide protection against all nine serotypes of the …

    cape-town Repository record

  20. Investigating the production of a particulate plant-produced vaccine candidate against African horse sickness

    Luhanga, GloriaDepartment of Molecular and Cell Biology2021

    … horses against AHSV. Virus-like particles (VLPs) that display antigens on their surface may be suitable vaccine platforms. One such display particle is the phage AP205 VLP, which is comprised of AP205 coat proteins. To aid antigen display, studies have utilized the SpyTag (ST) - SpyCatcher …

    cape-town Repository record

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