An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines

Previous studies from the HIV Vaccine Development Group at the University of Cape Town have reported that immunisation with recombinant modified vaccinia Ankara (SAAVI MVA-C) or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on HIV-1 subtype C are able to successfully induce vaccine specific responses in Chacma baboons. The aim of the current study was to characterise the T cell memory phenotype distribution in peripheral mononuclear cells (PBMCs) isolated from Chacma baboons vaccinated with SAAVI MVA-C/VLP and DNA/VLP prime-boost vaccination regimens by flow cytometry.

Grantor dc:publisher.institution

Division of Virology

Year dc:date.issued

2013

Author dc:creator

• Singh, Vedantha

Advisors dc:contributor.advisor

• Chege, Gerald
• Williamson, Anna-Lise

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/2738

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/2738