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Department of Molecular and Cell Biology
Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles
Abstract
dc:description.abstractIn this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA polyepitope DNA vaccine pTHr.HIVA. A range of in-frame fusions with the C-termini of myristylation-competent p6-truncated Gag and native Pr55gag were made to test how the length of polypeptide and its sequence might affect VLP formation and structure.
Degree
thesis:*- Grantor dc:publisher.institution
- Department of Molecular and Cell Biology
- Year dc:date.issued
- 2006
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Halsey, Richard James
- Advisors dc:contributor.advisor
-
- Tanzer, Fiona
- Jaffray, Ann
- Rybicki, Ed
Rights
- Language dc:language.iso
- eng
Identifiers
dc:identifier.*- Handle dc:identifier.uri
- http://hdl.handle.net/11427/4269
- OAI identifier oai:identifier
- oai:open.uct.ac.za:11427/4269