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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Tableting"”.
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Designing, building, and testing the spin, strip, and stomp mechanism for pharmaceutical tableting
Nanofiber fabrication of pharmaceutical pills creates significant advantages over conventional techniques such as shorter pill dissolution times, airborne drug particulate matter elimination, and shorter liquid drying time, among many others. Therefore, the Novartis MIT Center for Continuous …
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Physicochemical and tableting properties of crystallised and spray-dried phenylbutazone containing polymeric additives. Effect of polymeric additives (hydroxypropyl methylcellulose and a polyoxyethylene-polyoxypropylene glycol) on the crystalline structure, physicochemical properties and tableting behaviour of crystallised and spray-dried phenylbutazone powders
… the physicochemical, solid state, stability and tableting properties of a poorly aqueous soluble drug, phenylbutazone, in alternative polymorphic form and containing low levels of two hydrophilic polymers - hydroxypropyl methylcellulose (H. P. M. C. ) and the surfactant poloxamer 188 - prepared …
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A STUDY ON PARTICLE SURFACE ROUGHNESS AND ITS IMPACT ON TABLET AND INHALER TECHNOLOGY
… shape and size. In-die powder flow during tableting was studied using lactose particles of different surface roughness. Rougher particles had higher rearrangement energy requirement during tableting, decreasing the energy available for bond formation. The effects of roller compaction on …
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Studium tabletovin a tablet s retardující složkou obsahující hypromelosu a sodnou sůl karmelosy.
… Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium The thesis deals with the study of compressibility of directly compressible tableting materials containing coprocessed dry binders MicroceLac® …
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Role of Mechanical Stress, Excipients and Coprocessing On Tablet Mechanical Properties
… reducing the effect of compression speed during tableting scale-up was evaluated. Strain rate sensitivity (SRS) of compactibility profile was examined by evaluating the effect of speed on material deformation behavior. Mechanical parameters, namely Workc/d and tablet recovery (%), were used as …
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Immediate release ginseng chewable tablets and sustained release amino acid pellets based on dry powder coating technology platform
… chewable tablets, the content and types of tableting materials, as well as coating materials, coating temperature, curing time and coating level, were optimized. For the sustained release amino acid pellets, coating level and curing time on, as well as the composition of ethyl cellulose …
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A STUDY OF COMPRESSION DIE DESIGN ON THE COMPACTION OF PHARMACEUTICAL POWDER
… equipment configuration and tooling design. Tableting die is part of the compaction tooling and determines tablet size and shape. Dies with modified designs could potentially address tablet compaction issues, such as low tensile strength and elastic recovery, without the need for formulation …
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ΑΝΑΠΤΥΞΗ ΤΕΧΝΙΚΩΝ ΓΙΑ ΤΗ ΒΕΛΤΙΩΣΗ ΤΗΣ ΠΟΙΟΤΗΤΑΣ ΤΩΝ ΔΙΣΚΙΩΝ ΚΑΙ ΤΗΝ ΑΠΟΔΕΣΜΕΥΣΗΦΑΡΜΑΚΩΝ ΑΠΟ ΕΠΙΚΑΛΥΜΜΕΝΕΣ ΣΤΕΡΕΕΣ ΦΑΡΜΑΚΟΤΕΧΝΙΚΕΣ ΜΟΡΦΕΣ
… ALLOY COATING OF TOOLS (PUCHES AND DIE) OF A TABLETING MACHINE DECREASEDTHE EJECTION FORCE REQUIREMENT AND IMPROVED TABLET QUALITY, (II) A NEW AQUEOUS SYSTEM CONSISTED OF AGAROSE, MICROCRYSTALLINE CELLULOSE, HYDROXY- PROPYL METHYL-CELLULOSE (H.P.M.C) AND PEG-1000 YIELDS A MECHANICALLY STRONG, …
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Nanotechnology in pulmonary drug delivery: Compressible proliposome formulations for nebulization
… possessing good to excellent flowability. Upon tableting of sorbitol and D-mannitol, formulations at lipid to carrier ratios of 1:10 and 1:15 w/w; were viably compressible into tablets. Furthermore, sorbitol-based tablets at a ratio of 1:15 w/w were observed to be the only carrier-based …
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Modeling picking on pharmaceutical tablets
… fairly easy to control dosage. Pharmaceutical tableting operations have been around for decades however the process is still not well understood. One of the common problems faced during the production of pharmaceutical tablets by powder compaction is sticking of powder to the punch face, This …
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Tabletability Flip of Drugs upon Formulation
… properties, particle characteristics, and tableting conditions, while BS is governed by molecular packing and intermolecular interactions. The tabletability flip phenomenon (TFP), wherein an active pharmaceutical ingredient (API) with worse tabletability exhibits superior tabletability upon …
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Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance. Co-crystallization of urea/ 2-methoxybenzamide, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid systems: Solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour
… has affected the crystallinity as well as the tableting properties of the co-crystals. After the addition of excipients, the tensile strength of compacts was about 2 times higher than any other mixture. Finally, urea/ 2-MB and caffeine/ malonic acid co-crystals were successfully synthesized …
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The effect of speed of compression on the properties of compacts.
… maximum compression pressure exerted during the tableting cycle was found to be the major factor contributing to the tensile strength of the tablets. The use of a second compression either before or after the main compression was found to produce a significant increase in tablet tensile strength. …
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Estudio de prefactibilidad para la instalación de una planta productora de dentífrico en forma de pastillas
… the solid toothpaste, in a process known as Tableting. In the chapter about budgets and evaluation of the project, it was estimated that the total investment of the project would amount to S/ 1 050 005, which include tangible investment, intangible investment and working capital. The economic …
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Physicochemical and computational approaches for the prediction of the manufacturability of active pharmaceutical ingredients
… sticking and minimise production issues during tableting processes.
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Near-Infrared (NIR) Spectroscopy-based Pharmaceutical Process Analytical Technology (PAT) Systems: Risk and Performance
… predicting quality indices of powder blending, tableting, and roller compaction. The International Conference on Harmonization (ICH) Q9 guidance provides strategies for implementing quality risk management with respect to product development. This dissertation focuses on extending these concepts …
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Multi-Component Characterization of Strain Rate Sensitivity in Pharmaceutical Materials
… or concurrent consolidation mechanisms during tableting. It is commonly accepted that plastically deforming materials tend to be more strain rate sensitive than brittle materials, but this sensitivity depends on how fast the material can respond to applied stresses. In addition, since many …
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The design and manufacture of immediate-release optimal solid dosage forms
… drying, milling and screening, blending, tableting, coating, and so on. A new process, such as blending combined with solvent-less, multi-component injection-molding could greatly simplify manufacturing. Injection-molding, however, yields a non-porous material, intrinsically different from …
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Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
… of paracetamol is notorious for exhibiting poor tableting properties by direct compression, reduced plastic deformation during compression, commonly resulting in fragile tablets with a high propensity to cap. This work commences by providing insights into how, current and innovative processing …
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In-situ Study of Single Pharmaceutical Granule Drying using Synchrotron X-ray Imaging
… is a key unit operation in the pharmaceutical tableting industry. To ensure homogeneity and product quality for a wide range of formulations in the final tableted product, the monitoring of changes to an individual granules structure, and therein its composition and the associated properties, …
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