Designing, building, and testing the spin, strip, and stomp mechanism for pharmaceutical tableting

Nanofiber fabrication of pharmaceutical pills creates significant advantages over conventional techniques such as shorter pill dissolution times, airborne drug particulate matter elimination, and shorter liquid drying time, among many others. Therefore, the Novartis MIT Center for Continuous Manufacturing is prioritizing development of electrospinning techniques for producing nanofibrous pills. However, electrospinning pills still has a very low production rate compared to that of the current pharmaceutical techniques. Motivated by the need for an efficient and effective elecrospinning technique, we developed the "Spin, Strip, and Stomp Mechanism." This technique has successfully made pills of the required quality, designed with the goal of reducing the gap between the low production rates of nanofibrous pills and the high rates of the current pill making techniques.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2017

Author dc:creator

• Labib, Shahd Hassan

Advisor dc:contributor.advisor

• Alexander Slocum.

• Mechanical Engineering.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/111727

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/111727