Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 137 for “"THC"”.
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Behavioral Mechanisms of Δ9-THC in Nonhuman Primates
… consequences of Δ9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, is critical for developing treatments in cannabis dependent patients. Despite the fact that marijuana is the most commonly abused illicit substance in the U.S., self-administration (SA) of THC …
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Der Einfluss von Delta-9-THC auf Lernen und Gedächtnis
… Furchtreaktion durch 10 mg Delta-9-THC (Tetrahydrocannabinol) zu untersuchen. Die Konditionierung erfolgte mittels eines differentiellen Verzögerungsparadigmas unter Beobachtung der konditionierten Reaktion auf subjektiven und peripherphysiologischen Parametern. Eine implizite …
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Estudios de efectos neurobiológicos del Δ9-tetrahidrocannabinol (THC) en modelos animales
… activo, el Δ9- tetrahidrocannabinol (Δ9-THC) ( Mechoulam y Gaoni, 1965). Dicho hallazgo supuso el inicio para años de investigación fructífera, los cuales se encuentran resumidos en las referencias que se muestran en la tabla 1. Los compuestos cannabinoides son algo más que los …
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THC-MEDIATED INDUCTION OF ΔFOSB AND ITS MODULATION OF CB1R SIGNALING AND ADAPTATION
… therapeutic effects of Δ9-tetrahydrocannabinol (THC) are mediated through cannabinoid type 1 receptors (CB1Rs). The therapeutic uses of THC are mitigated by the development of tolerance to these therapeutic effects, whereas tolerance does not readily develop to some of the side-effects of THC, …
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The Effects of Δ9-tetrahydrocannabinol (THC) on development and hyperekplexia in embryonic zebrafish model
… plant, Δ<sup>9</sup> – tetrahydrocannabinol (THC) has been shown to the most efficacious phytocannabinoid in neurological disorders. THC has been shown in numerous previous studies to be effective at treating spasticity caused by multiple sclerosis and spinal cord injury, as well as seizures. …
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Il Δ9-THC, componente principale della cannabis sativa, attenua la neurotossicità indotta dalla meth
… that natural (Δ9-tetrahydrocannabinol, Δ9-THC) and synthetic cannabinoid CB1 receptor agonists exert neuroprotective effects in different models of cerebral damage, including excitotoxic injury [Deng X and Cadet JL, 2009; La Voie MJ, et al. 2004]. In this study we evaluated the …
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A New Method for the Synthesis of the Terpene Precursors for the Terpene Portion of Δ-1-Tetrahydrocannabinol (THC).
Marijuana and hashish have been under focus in recent years by governmental, social, and scientific groups. This attention has triggered the study of chemistry of cannabis sativa, cannabis indica, and other types of plants thought to contain cannabinoid. material. These studies have led to many new …
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EFFECTS OF ACUTE THC ADMINISTRATION ON EXTINCTION OF CONDITIONED FEAR RESPONSES IN HUMANS: A FUNCTIONAL ANALYSIS OF HIGH DENSITY EEG
… effects of acute delta 9-tetrahyrdrocannabidol (THC) administration on extinction of conditioned fear responses. Fear conditioning was initiated using a differential classical conditioning paradigm that paired an aversive unconditioned stimulus (shock) with a signaling stimulus (CS+), whereas …
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Cannabinoids and Psychosis – Cause and Treatment
… active ingredient is Δ-9-Tetrahydrocannabinol (THC). In healthy humans, the acute administration of THC can elicit transient psychotic symptoms and cognitive impairment. THC stimulates the endocanabinoid CB1 receptor (CB1R). However, beyond CB1Rs, the mechanism underlying the pro-psychotic …
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Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen
… Drogen steht Cannabis (Hauptinhaltstoff Delta-9-THC) seit über 30 Jahren auf Platz eins in Deutschland und Europa. Des Weiteren wird THC in der Medizin zunehmend auch therapeutisch eingesetzt und ist heute Gegenstand zahlreicher Studien. Methoden: In dieser Studie untersuchten wir den Einfluss …
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The use of tetrahydrocannabinol (marinol) in cancer patients undergoing chemotherapy
… contains the antiemetic tetrahydrocannabinol (THC), was evaluated in five cancer patients undergoing chemotherapy. Subjects rated their nausea and vomiting, food intake, appetite and mood status three times daily. Drug therapy (THC) or no drug was administered for an average of four months …
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Preparation and Characterization of Lyophilized Cyclodextrin Complexes of a Hemisuccinate Ester of Delta-9-Tetrahydrocannabinol for Transmucosal Delivery
Delta-9- Tetrahydrocannabinol (THC) is the primary active ingredient of the plant Cannabis sativa (marijuana), responsible for the majority of the pharmacological effects. The most promising clinical applications of THC approved by the Food and Drug Administration (FDA) are for the control of …
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The Effects of Methanol and Isopropanol on the Chiral Separation of Dronabinol and Three Related Impurities: A 3 X 3 X 3 Factorial Design
The enantioseparations of Δ9-THC and Δ8-THC on amylose tris dimethylphenylcarbamate CSP was investigated using mobile phases containing 1-3% methanol with 1-7% IPA in n-heptane. A factorial design was used to study the main and interaction effects of these alcohols as measured by the retention …
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Cyclodextrins as a suitable carrier for the induction of feeding and analgesia by Delta-9 THC: a preclinical study in the female rat
… oral delivery of Δ9-tetrahydrocannabinol (THC) remains challenging due to the compound’s low aqueous solubility, extensive first-pass metabolism, and variable pharmacokinetics. This research explores whether complexing THC with hydroxypropyl-β-cyclodextrin (HP-β-CD) can overcome these …
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Single Liquid-Liquid Extraction of Delta-9-Tetrahydrocannabinol and 11-<i>Nor</i>-Carboxy-Delta-9-Tetrahydrocannabinol at an Acidic pH
… cases, it is important to test for both delta-9-THC and delta-9-THCA in order to determine current and recent usage. The laboratory preparation and analysis of delta-9-THC and delta-9-THCA in urine should be as cost and time efficient as possible. Current extraction of delta-9-THC and …
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Effects of oral delta-9-tetrahydrocannibinol (THC) administration on motor activity and anxiety-like behavior in adolescent and adult Sprague-Dawley rats of both sexes
… component delta-9-tetrahydrocannabinol (THC) may induce modifications in neural circuitry that in turn lead to adverse consequences on behavior. Previous literature has suggested that intraperitoneal, intragastric, or subcutaneous administration of THC may produce an anxiogenic effect and …
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A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… constituent, delta-9-tetrahydrocannabinol (THC), is gaining acceptance. However, there are no currently approved pharmacotherapies to treat cannabinoid withdrawal. The objective of this thesis was to evaluate whether elevating endogenous anandamide levels using mice lacking fatty acid amide …
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Effects of acute and repeated cannabinoid injections on immediate and delayed object memory and unconditioned anxiety – a developmental trajectory
… of cannabinoids such as Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which are found in the cannabis plant, can lead to disruptions in well-maintained inhibitory signaling. Although marijuana usage rates have been relatively stable since 2002, the number of young adolescents and adults …
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