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Showing 1 to 20 of 20 for “"SPECT/CT"”.
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Simultaneous ⁹⁹m̳Tc-MDP/¹²³I-MIBG imaging of neuroblastoma using SPECT-CT
Simultaneous ⁹⁹m̳̳Tc-MDP/ ¹²³I-MIBG SPECT has the potential to replace current clinical sequential acquisitions of ⁹⁹m̳Tc-MDP and ¹²³-MIBG SPECT studies, and therefore has great potential to reduce imaging time, sedation time, and injection dose on patients with neuroblastoma. Simultaneous …
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Image Quality Optimisation and Dose Management in CT, SPECT/CT, and PET/CT
The significant increase in the use of CT, alone or combined with SPECT or PET, has raised concerns about patient radiation exposure and the consequent increased risk of malignancy later in life. The overall objective of this work was to evaluate and optimise different approaches for minimising …
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Evaluation of a Dedicated SPECT-CT Mammotomography System for Quantitative Hybrid Breast Imaging
… the single photon emission computed tomography (SPECT) subsystem of a dedicated three-dimensional (3D) dual-modality breast imaging system for enhanced semi-automated, quantitative clinical imaging. This novel hybrid imaging system combines functional or molecular information obtained with a …
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Assessment of the impact of the application single photon emission computerized tomography and SPECT-CT on lesion catergorization
Objectives: To assess initial experience with the use of a new SPECT-CT in the evaluation of lesions. Methods: The folder number, radiopharmaceutical used and type of scan of patients examined with a new Siemens T6 SPECT-CT between 2 April and 31 December 2013 were retrieved. The number of 99m Tc …
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Optimizing PSMA scintigraphy for resource limited settings – a retrospective comparative study
… underwent PS with full-body planar and multi-FOV SPECT/CT were reviewed. The detection rates for uptake in the prostate gland/bed and in metastases were compared on planar, SPECT, and SPECT/CT. The agreement between modalities was calculated for the detection of metastases and for staging. The …
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Evaluation of the effect of breast implants on the accuracy of the CT attenuation Correction (CTAC) map for SPECT/CT myocardial perfusion imaging: a phantom study
… using single photon emission computedtomography (SPECT) imaging can assess myocardial viability and perfusion. However,overlying thoracic structures, such as ribs or breast tissue lead to gamma ray attenuation. Thisattenuation does not occur equally for all body regions. Photons emitted from …
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IMPROVING RESOLUTION IN WRIST SPECT WITH CONVERGING COLLIMATORS AND CT ANATOMICAL PRIORS
… medicine offers a high sensitivity for fracture detection, but low specificity. Improving resolution could lead to better specificity. We hypothesize that wrist SPECT resolution can be improved by using pinhole collimators and by incorporating anatomical prior information. Phantom …
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Prognostication and disease monitoring in fibrotic interstitial lung disease
Introduction Fibrotic interstitial lung disease (f-ILD) causes significant morbidity and mortality worldwide. Progressive pulmonary fibrosis (PPF) describes a cohort of patients who develop progressive disease despite standard treatment. To provide optimal care, it is vital to identify those …
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Development of a novel imaging system for cell therapy in the brain.
… the identification of underlying mechanisms of action. Currently, the lack of a reliable and safe method to accurately and non-invasively locate the site of implantation and track the migration of stem cells in vivo hampers the development of stem cell therapy and its clinical application. The …
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Bias and Variability In Image-Based Volumetric Yttrium-90 Dosimetry
… the patients are ineligible for surgical resection and external beam radiation therapy. The prognosis of untreated patient having liver cancer is very poor with life expectancy less than a year at advance stage. Hence the ability to predict treatment efficacy right after the treatment from …
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Pretargeted cancer radioimmunotherapy and radioimaging using antibodies and antibody fragments
… (RIT), tumor targeting antibodies are directly conjugated with radioisotopes and depending on the radionuclides's properties, the direct labeled antibodies can be used for diagnostic or therapeutic purposes. However, one of the major challenges of using radiolabeled antibodies for therapy …
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Preclinical imaging of prostate cancer using radiolabeled antibodies
… presence and extent. Despite all efforts to detect and control prostate cancer at an early stage, a number of men are still progressing to develop incurable metastatic disease. Because of this, development of new methods based on target-specific imaging is becoming increasingly important in the …
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Κλινική αξιολόγηση του λογισμικού εσωτερικής δοσιμετρίας QDOSE+ σε περιπτώσεις ασθενών υπό θεραπεία με Lu-177: σύγκριση με το λογισμικό PLANET Onco Dose
… χρησιμοποιώντας ποσοτικοποιημένες εικόνες SPECT/CT από θεραπείες με Lu 177 και εξετάζοντας διαφορές σε όγκο, αθροιστική ενεργότητα και απορροφούμενη δόση. Παράλληλα, διερευνήθηκε η επίδραση της μείωσης των χρονικών σημείων λήψης από τέσσερα σε τρία στο QDOSE+, η επίδραση της κοινής …
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A Pretargeted Spect Imaging Strategy Employing Technetium-99M Based on Bioorthogonal Diels-Alder Click Chemistry
… synthesized and tested for use in pretargeting SPECT imaging that utilizes the bioorthogonal Diels-Alder click reaction between tetrazine (Tz) and transcyclooctene (TCO). The objective was to optimize the excretory pathways of the <sup>99m</sup>Tc-peptide complexes for maximum tumor targeting …
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Radiomarcação de células do sangue periférico com 99mTc (Tecnécio- 99m) para estudos de sangramentos gastrointestinais e cardiopatias
… de 6 horas, emissão gama de 140 keV e suas características físico-químicas, que permitem a produção de complexos diferenciados de fácil marcação. Na modalidade SPECT/CT (Tomografia Computadorizada por Emissão de Fóton Único) a aquisição de imagens a partir da marcação de células do sangue …
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Über die quantitative multimodale Auswertung der prä-, intra- und posttherapeutischen Bildgebung zur Erfassung der Wirksamkeit (inklusive prädiktiver Aussage) der Radiosynoviorthese des Kniegelenkes mit Y-90-Kolloid
… beinhaltete eine prä- und posttherapeutische xSPECT, welche eine Quantifizierung mit Messung des SUVmax-Wertes und eine intratherapeutische Y-90-PET/CT beinhaltete. Es zeigte sich, dass es prätherapeutisch intraindividuell signifikante Unterschiede zwischen den SUVmax-Werten von Kniegelenken …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… powder drug delivery vehicle containing 70% lactose (w/w), 20% SPIONs (w/w) and 10% fluorescent nanospheres (w/w). Mice were insufflated with NIMs delivery vehicle in the presence of magnetic field dependent targeting to the left ventral lung after thoracotomy; controls were insufflated with …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… mortality (6.9%) rates. Human epidermal growth factor receptor 2 (HER2) is overexpressed in 20-30% of BC. HER2 overexpression is also observed in other cancers such as gastric/gastroesophageal, ovarian, lung, prostate, bladder, colon and head and neck. HER2-positive BC is characterized by …