Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"Progesterone Receptor"”.
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Suppression of Cervical Cancer by the Progesterone Receptor Signaling
… women, implicating a role of estrogen and progesterone in cervical cancer. Prior studies utilizing an HPV transgenic mouse model expressing E6 and E7 (K14E6/K14E7) have demonstrated the requirement of estrogen receptor alpha (ERα) and estradiol (E2) for cervical carcinogenesis. Accumulating …
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The role of progesterone receptor in hypothalamic kisspeptin neurons
… Kisspeptin neurons express steroid hormone receptors through which gonadal steroids exert both positive and negative feedback to the hypothalamus; estrogen and its receptor, estrogen receptor α (ERα), have been shown to regulate kisspeptin-mediated GnRH release through regulation of …
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Small molecule inhibitors: novel probes of progesterone receptor action
The progesterone receptor (PR) is an important member of the nuclear receptor superfamily of transcription regulatory proteins. It plays vital roles in a diverse set of biological processes, from homeostasis to reproduction. PR’s major function involves binding of liganded receptor to DNA and …
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Regulation of progesterone receptor expression and activity in uterine cells: Analysis of the molecular actions of estrogens and progestins on the progesterone receptor gene
… exert their effects via intracellular protein receptors, termed estrogen receptors (ERs) and progestin receptors (PRs). We have examined the regulation of PR levels in the rat uterus by estrogens and progestins, as well as the molecular mechanisms through which these hormones act. Our studies …
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Estrogen Receptor and Progesterone Receptor Synthesis and Degradation in Target Cells
… of synthesis and degradation of steroid hormone receptors are crucial factors in maintaining hormone responsiveness in target tissues. It was the intent of this study to determine the turnover of the estrogen receptor (ER) and progesterone receptors (PR) in rat uterine and human breast cancer …
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Progesterone Receptor Regulation of the Gene Networks That Control Ovulation in Mice
… over the past twenty years, the steroid hormone progesterone, which exerts its biological effects through the progesterone receptors (PR), has emerged as a key regulator of ovulation. The development of progesterone receptor (PR)-null mice, which are unable to ovulate, revealed a critical role of …
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Progesterone receptor targets play critical roles in maintaining pregnancy and disease prevention
The ovarian hormone progesterone influences many facets of uterine physiology through the transcriptional activity of progesterone receptor (PR). This body of work investigates the role of progesterone receptor targets heart and neural crest derivatives expressed 2 (HAND2) and insulin receptor …
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Modulation of the progesterone receptor by progestogens, antiretroviral drugs and the glucocorticoid receptor
… has not been determined via their target steroid receptor (SR), the progesterone receptors and its isoforms (PR-A and PR-B). This thesis involves an in vitro investigation of some of the factors that affect PR activity and that may thus impact progestogen responses in women on HC or HRT. These …
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Relative level of glucocorticoid and progesterone receptor: implications for immune and reproductive functions in women
Background: The glucocorticoid receptor (GR) and progesterone receptor (PR) are very closely related in terms of their amino acid sequence and three-dimensional structure. PR ligands have been previously reported to cross-react with the GR. The cross-talk effects of certain PR ligands via the GR …
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Estrogen Receptor and Progesterone Receptor Synthesis and Degradation in Breast Cancer Cells (Turnover, Precursor, Density Shift, Dense Amino Acids)
… and degradation rates of the estrogen and progesterone receptors in a human breast cancer cell line and investigating the effect of ligand (both agonist and antagonist) binding on these rates.
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Cross talk between the glucocorticoid receptor and the progesterone receptor in modulation of progestin responses and HIV-1 infection
… injectable contraceptive progestin Depotmedroxyprogesterone acetate (DMPA) is associated with increased HIV-1 acquisition is controversial. However, animal and ex vivo data reveal plausible biological mechanisms whereby MPA may increase HIV-1 acquisition. Relatively high levels of endogenous …
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The impact of variation in the progesterone receptor gene, life history and lifestyle on endometrial function and the menstrual cycle
… by the available data. A polymorphism in the progesterone receptor gene, called PROGINS, shows diminished progesterone response in vitro and is associated with a number of uterine disorders in women. To elucidate the discrepancy between ovarian and uterine markers of fecundity, carriers of the …
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Biological Potencies and Mechanism of Action of Estrogens and Antiestrogens in Primary Cell Cultures of Human Endometrium and in Mcf-7 Human Breast Carcinoma Cells in Vitro
… to examine the direct effects of estrogens on progesterone receptor levels in vitro. Cells, grown in Dulbecco's EMEM, showed maximal stimulation of progesterone receptor (PR, 7-fold) after a 3-4 d incubation with 10nM estradiol (E(,2)). The
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ΜΕΛΕΤΗ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΓΕΣΤΕΡΟΝΗΣ ΣΤΗΝ ΑΝΘΡΩΠΙΝΗ ΜΗΤΡΑ: ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΚΑΙ ΚΑΘΑΡΙΣΜΟΣ ΤΟΥ ΜΟΡΙΟΥ
HUMAN UTERUS IS A TARGET TISSUE OF PROGESTERONE AND THEREFORE IS SUITABLE FOR THE STUDY OF THIS RECEPTOR. HOWEVER THIS TISSUE IS ALSO VERY RICH IN PROTEOLYTIC ENZYMES. PROTEASE INHIBITORY AND SODIUM MOLYBDATE ARE USED FOR THE CONTROL OF PROTEOLYSIS AND THE PROTECTION OF THE HOLORECEPTOR. …
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Neuroendocrine regulation of broodiness in the domestic hen
… behaviour is initiated by increased plasma progesterone and oestrogen from maturing ovarian follicles that induce nesting behaviour. This is subsequently transformed into incubation behaviour by increased plasma prolactin in association with decreased gonadotrophin and ovarian steroid …
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Interrelationships among estrogen, insulin-like growth factor-I and cyclic adenosine monophosphate in the regulation of uterine progesterone and estrogen receptors
Studies were undertaken to examine regulation of progesterone receptor gene expression and estrogen receptor bioactivity in uterine cells, and to determine the cellular mechanisms through which various factors mediate regulation of these receptor proteins. Exposure of uterine cells maintained in …
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Modulation of gene expression by estrogen and protein kinase activators in MCF-7 human breast cancer cells
… cells, which contain high levels of estrogen receptor and low levels of progesterone receptor.
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I. Molecular Probes for the Progesterone Receptor. II. Design and Synthesis of a Rigidly Constrained Peptidomimetic as a Potential Beta-Turn Mimic. III. Isolation and Characterization of Novel Ion Channel Modulators From Commercial Phenol Red Preparations
Chemical probes for steroid receptors have proven useful in providing molecular details about important hormone-receptor interactions. $16\alpha,17\alpha$- ((R)-1$\sp\prime$-(4-Azidophenyl)-ethylidenedioxy) pregn-4-ene-3,20-dione (12) was prepared in high specific activity tritium-labeled form (20 …
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Molecular Mechanisms for the Angiotensin-(1-7)-Mediated Inhibition of Metastatic Triple Negative Breast Cancer
… triple negative, wherein tumors lack estrogen receptor and progesterone receptor expression and possess unamplified human epidermal growth factor receptor 2 (HER2) levels, contributing to an absence of effective, targeted therapeutics. Furthermore, triple negative breast cancer (TNBC) is …
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Factors controlling the expression of central progesterone receptors
Progesterone, a steroid hormone is closely associated with a variety of behavioural and neuroendocrine functions. Studies were undertaken to identify the control of progesterone receptor (PR) expression in avian brain tissue. In the first study, glial cells taken from newly hatched ring doves …
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