Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"PpIX"”.
-
LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
… and high mortality. Protoporphyrin IX (PpIX) accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation …
-
Interactions of ferriprotoporphyrin IX with neutral lipids and detergents: insights into their role in β-haematin formation
… to amino acids and ferriprotoporphyrin (Fe(III)PPIX), that it subsequently detoxifies to form the bio crystal, haemozoin. Neutral lipids have been implicated as the biological molecules responsible for the nucleation of haemozoin in vivo, though their exact role is unclear. This thesis has …
-
Encapsulation of iron(III) protoporphyrin IX and tetraphenylporphyrin in metal-organic frameworks for application as heterogeneous oxidation catalysts
… Fe(III) protoporphyrin IX (ferrihaem = Fe(III)PPIX) and Fe(III) tetraphenylporphyrin (Fe(III)TPP). Methyl orange (MO) adsorption was used as an initial model for substrate uptake in MOFs 1 and 2. MOF 1 showed good adsorption of MO (10.3 ± 0.8 mg.g-1 ) which could undergo in situ protonation …
-
Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
… interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, imidazoles, amines and …
-
In vitro modelling of cellular haemozoin and inhibition by β-haematin inhibitors and their derivatives
… the parasite digestive vacuole and form a Fe(III)PPIX-inhibitor complex by accumulating at high concentrations which consequently inhibits parasite growth. Another important focus is on understanding the digestion of haemoglobin and its role in haemozoin formation. This research investigates the …
-
Pharmakokinetische, fluoreszenzmikroskopische Studie zur Gewebeaufnahme und Verteilung von 5-Aminolävulinsäure aus 5-ALA-Thermogel bei zervikaler intraepithelialer Neoplasie (CIN 1-3)
… durchgeführten Untersuchungen zeigen, dass die PPIX-Fluoreszenz ihr Maximum bei der Applikation von 10%igem 5-ALA-Thermogel und einem Inkubationsintervall von über 2 Stunden erzielt. Eine höhere Konzentration des 5-ALAThermogels verursachte keinen weiteren Anstieg der PPIX-Fluoreszenzintensität. …
-
OPTIMIZED APPROACHES FOR LIQUID BIOPSY IN GLIOBLASTOMA PATIENTS
… (5-ALA)–induced protoporphyrin IX (PpIX) fluorescence, and focused-ultrasound blood–brain-barrier opening (FUS-BBBO). The objective is to determine whether they can aid in collecting accurate, real-time information on tumour burden and biology, thereby laying the groundwork for …
-
Quantum dot labelled antimalarials and investigation of their interaction with synthetic haemozoin
… the levels of toxic ferriprotoporphyrin (Fe(III)PPIX) present in the DV. Chloroquine is supposed to be adsorbed onto the fastest growing face of the crystal, inhibiting the growth and increasing the amount of toxic Fe(III)PPIX; however, the mechanism of this interaction is still largely unproven. …
-
Protoporphyrin IX distribution in rat brain following the administration of 5-aminolevulinic acid and its hexylester
… microscopy was performed to quantify PpIX production. Results indicate that PpIX production in tumor tissue is greater following 5-aminolevulinic acid administration than h-ALA. However, the tumor-to-normal tissue uptake ratio is superior following injection of h-ALA (7.6 +/- 2.0:1) …
-
Characterization of the Hepatotoxicity of Rifampicin and Isoniazid
… with an increase of protoporphyrin ix (PPIX), the penultimate heme precursor. Excess PPIX is believed to bind to bile acids, precipitate in bile canaliculi, and form bile plugs leading to cholestasis fol owed by liver injury. Both ferrochelatase (<em>FECH</em>/<em>Fech</em>) and …
-
Metabolic Exogenous Contrast Agents for use in Breast Cancer Detection and Therapy Monitoring
… molecularly specific agents, protoporphyrin IX (PpIX) and 2-NBDG, which utilize metabolic alterations caused by cancer, can be used for ubiquitous breast cancer differentiation and therapy monitoring. Confocal microscopy is used to demonstrate the applicability of both agents in vitro to breast …
-
Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds
The nature of the ferriprotoporphyrin IX (Fe(III)PPIX) antimalarial drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of …
-
The Development of Peptide Analogues as Potential Fluorescent and PET Imaging Probes.
… coordinate metals. A gallium-protoporphyrin IX(PPIX)-ghrelin based analogue was designed as a potential dual PET/fluorescence imaging probe for detection of growth hormone secretagogue receptor 1a (GHS-R1a) and it was found that fluorescence was not quenched upon coordination to Ga. The …
-
Synthesis of 1,4 Dihydropyridines as potential antimalarial chemotype
… microcrystalline ferriprotoporphryin IX [Fe(III)PPIX] dimer called haemozoin as an end-product, also arises as a result of the degradation. This haem detoxification pathway is a principal target for some of these antimalarials, especially those that contain the quinoline scaffold (e.g …
-
Enhance heme biosynthesis in Saccharomyces cerevisiae
… and its direct precursor, protoporphyrin IX (PpIX). The challenges encountered in the high-throughput screening for mutants with enhanced heme production underscored the need for more refined detection methods to identify and quantify metabolic improvements accurately. This research …
-
Discovery of benzamides and triarylimidazoles active against Plasmodium falciparum via haemozoin inhibition : high throughput screening, synthesis and structure-activity relationships
… a cytotoxic accumulation of free haem (Fe(III)PPIX) in the parasite, a target which remains promising for future treatments. Much research has been undertaken on the quinoline antimalarials, which has led to several hypotheses of haemozoin inhibition and drug accumulation mechanisms, however, …
-
Characterizing a structural and functional model of nitric oxide reductase performing NO and O2 reduction in engineered myoglobin
… was previously unexplored, but replacement of Fe-PPIX with Zn-PPIX allowed for detailed spectroscopic characterization of the nonheme Fe-nitrosyl species.8 Enrichment of each site with 57Fe allowed for advanced NRVS measurements of all vibrational modes of the 57Fe sites, as well as any …
-
Insights into the mechanism of action of quinoline antimalarials against Plasmodium falciparum revealed by novel fluorescent analogues and chemical proteomics
… target, ferriprotoporphyrin IX or Fe(III)PPIX. Versatile derivatisation of the alkaloids was enabled by a regioselective radical-mediated thiolene click reduction. 7-Nitrobenz-2-oxa-1,3-diazole (NBD) was identified as a suitable reporter fluorophore and was attached to the quinoline core …
-
A cancer-targeting liposomal delivery system for photodynamic diagnosis and therapy of cancers in peritoneal cavity
… loaded with MAL can enlarge the gap between PpIX accumulation in tumor cells and normal tissues. c) FL system loaded with MAL can provide photodynamic diagnosis and photodynamic therapy as complementary functions.
-
Clinical study of the use of Photodynamic Detection (PDD) in assessing suspicious oral lesions
… in highly active cells to protoporphyrin IX (PpIX). Excitation of a cell at 405nm wavelength (light) leads to emission of autofluorescence at 500nm and PpIX at 635nm. The purpose of this investigation was to evaluate the use of compact spectroscopy together with the photosensitizer prodrug …
Page 1 of 2