Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds

The nature of the ferriprotoporphyrin IX (Fe(III)PPIX) antimalarial drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of over 100 parasite species found in reptiles, birds and mammals. The four species of plasmodia that infect man are P. vivax, P. malariae, P. ovale and P. falciparum; of which P. falciparum is the most deadly (Bruce-Chwatt 1981 ).

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2002

Author dc:creator

• Kaschula, Catherine Hart

Advisors dc:contributor.advisor

• Egan, Timothy J
• Hunter, Roger

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/6316

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/6316