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Showing 1 to 20 of 25 for “"PRx"”.

  1. Investigating cerebrovascular pressure reactivity in a large cohort of children with severe traumatic brain injury

    Smith, Claudia AnnDepartment of Human Biology2021

    … TBI. This study aimed to describe the profile of PRx, a mathematical indicator of cerebrovascular pressure reactivity, in a large cohort of children with severe TBI. The specific aims were to 1) describe the characteristics of PRx; 2) examine associations between PRx, clinical and physiological …

    cape-town Repository record

  2. The Role of Peroxiredixin Ⅲ in the ototoxic drug-induced mitochondrial apoptosis of cochlear hair cell

    최, 호석2011

    … glutathione peroxidase, and peroxiredoxin(Prx). The newly identified Prx family of peroxidases includes at least six isoforms in mammalian cells. Among them, Prx III is synthesized with a mitochondrial targeting sequence and is then transferred to mitochondria. We have shown that Prx III is …

    ajou Repository record

  3. Study on the Physical and Functional Interaction between Fortilin and Peroxiredoxin I

    Chattopadhyay, AbhijnanThe University of Texas Medical Branch at Galveston2016

    … the anti-oxidant enzyme peroxiredoxin I (Prx I). Prx I is a thioredoxin-dependent peroxidase enzyme that is known to be protective against reactive oxygen species (ROS)-induced cell death. We confirmed the interaction between FT and Prx I by using various approaches, including reverse …

    utmb Repository record

  4. Expression of Prxiredoxin I, III and Thioredoxin in human lung cancer and the normal lung tissues

    김, 영선2011

    … of novel antioxidant proteins, peroxiredoxins (Prxs), have been implicated in regulating many cellular processes including cell proliferations, differentiation, and apoptosis. They are also reported to function as an oxidative stress-dependent molecular chaperone for many important cellular …

    ajou Repository record

  5. Cerebral autoregulation in children with traumatic brain injury: Comparing the autoregulatory index (ARI) to pressure reactivity index (PRx) and their associations with cerebral physiological parameters

    Patel, MaryamDivision of Neurosurgery2017

    … between two autoregulatory indices, namely PRx (pressure reactivity index) and ARI (autoregulatory index) in children with severe TBI. The study also examined their relationship with the response of clinically relevant variables such as intracranial pressure (ICP), brain oxygenation (PbtO2) …

    cape-town Repository record

  6. Nrf2-Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer, Especially Squamous Cell Carcinoma

    김, 영선2011

    … analysis 11 Ⅲ. RESULTS 12 A. Localization of Prx III and Srx in A549 cells 12 B. Oxidation of Prx III in mink lung epithelial cells 12 C. Srx dependent regulation of Prx III oxidation in A549 cells 15 D. Srx is translocated into the mitochondria under oxidative stress 15 E. Overexpression of …

    ajou Repository record

  7. Nanocarriers for drug targeting and improved bioavailability

    CORRIAS, FRANCESCOUniversità degli Studi di Cagliari2014

    … dermal delivery and stability. Piroxicam (PRX) is a non-steroidal anti-inflammatory drug characterized by a poorly water solubility and consequently by a low oral bioavailability. Different nanocrystals orally disintegrating tablets (ODT) were prepared to enhance piroxicam dissolution …

    cagliari Repository record

  8. Mechanisms of Cerebral Autoregulation in Traumatic Brain Injury

    Smith, Claudia AnnUniversity of Cambridge2025

    … data regarding the pressure reactivity index (PRx), with existing data limited to small or retrospective single centre studies. Studying Trends in AutoRegulation in Severe Head Injury in Paediatrics (STARSHIP) is the first multicentre prospective trial and aimed to characterise PRx in 135 …

    cambridge Repository record

  9. Functional stability of plant peroxiredoxins

    Jacob, SimoneUniversität Bielefeld

    Peroxiredoxins (Prx), a ubiquitous superfamily of peroxidases, are an important component of the antioxidant network of the cell, with members of the subgroups of 2-Cys Prx and type II Prx being in focus of the present work. A comparative characterisation of cytosolic PrxII B and PrxII C was …

    bielefeld Repository record

  10. Studies in Peroxiredoxin Hyperoxidation Sensitivity

    Bolduc, JesalynWake Forest University2016

    Prxs are a family of antioxidant proteins that are the predominant peroxidase within the cell. This thesis research focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation …

    wfu Repository record

  11. Quantifying methodological uncertainties and navigating feasibilities in monitoring of cerebral autoregulation - Towards individualised management of TBI.

    Beqiri, ErtaUniversity of Cambridge2024

    … periods of data where the pressure reactivity (PRx) metric calculations were invalid. The reliability of automated PRx-derived optimal cerebral perfusion pressure (CPPopt) estimates was also addressed, with a special focus on prospective bedside application. Finally, Part III examines the …

    cambridge Repository record

  12. KINETIC, THERMODYNAMIC AND MECHANISTIC FEATURES OF ESCHERICHIA COLI BCP, AN UNUSUALLY VERSATILE PEROXIREDOXIN

    Reeves, Stacy A.Wake Forest University2011

    … by definition is a peroxiredoxin (Prx) which catalyzes the reduction of hydrogen peroxide and organic hydroperoxides. <italic>Ec</italic>BCP is a member of the most poorly characterized and least studied Prx subfamily. The experiments and data presented in this thesis were …

    wfu Repository record

  13. Continuous Multi-Modal Monitoring of Cerebrovascular Reactivity in Adult Traumatic Brain Injury

    Zeiler, Frederick AdamUniversity of Cambridge2019

    … has focused on pressure reactivity index (PRx), which has emerged as the “gold standard” for continuous monitoring of cerebrovascular reactivity in adult TBI, but many questions concerning its clinical utility remain unanswered. The focus of this thesis was to address some of these …

    cambridge Repository record

  14. Testing k-wise independent distributions

    Xie, Ning, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2012

    … . . , ik} and for any zi E Ei 1, .. , Zk E Eik , PrX~D [Xi 1 - - -Xi, = Z1 .. z] = PrX-D[Xi 1 = zi] ... PrX~D [Xik = Zk]. k-wise independent distributions look random "locally" to an observer of only k coordinates, even though they may be far from random "globally". Because of this key feature, …

    mit Repository record

  15. Expression of Peroxiredoxin Induced by Silica in Alveola Epithelial Cells

    이, 혜림2011

    … 있다. 비교적 최근에 알려진, 새로운 계통의 항산화 효소인 peroxiredoxin (Prx)은 세포의 증식과 분화, 세포사멸이나 발암과정에 관여하는 것으로 알려져 있다. 더구나, 이들 Prx 는 thioredoxin (Trx)과 더불어 열충격이나 산화스트레스에 의존적인 분자 생물학적 스위치로서, peroxidase 와 chaperone 기능과의 사이를 조절하는 것으로 알려져 있다. 하지만, 현재까지 폐암을 비롯한 각종 질병에서의 이들 Prx의 역할은 잘 규명되어 있지 않으며, 분해 및 대사과정에 대한 연구는 부족한 실정이다. …

    ajou Repository record

  16. <i>Plasmodium</i>-Induced Nitrosative Stress in <i>Anopheles stephensi</i>: The Cost of Host Defense

    Peterson, Tina Marie LoaneVirginia Tech2005

    … self damage. I proposed that peroxiredoxins (Prx), enzymes that can detoxify peroxides and peroxynitrite, may protect <i>A. stephensi</i> from nitrosative stress. Six Prx genes were identified in the <i>A. gambiae</i> genome based on homology with known <i>D. melanogaster</i> Prxs. I …

    vt Repository record

  17. Optimization of the assessment of cerebral autoregulation in neurocritical care unit

    Liu, XiuyunUniversity of Cambridge2017

    … (CBFV) and CPP; and pressure reactivity index (PRx), calculated as a moving correlation coefficient between mean arterial blood pressure (ABP) and intracranial pressure (ICP). However, until now, how these parameters are related with each other is still not clear. A comprehensive investigation …

    cambridge Repository record

  18. STRUCTURAL AND CATALYTIC FEATURES AFFECTING INACTIVATION OF TYPICAL 2-CYS HUMAN PEROXIREDOXINS 2 AND 3

    Haynes, AlexinaWake Forest University2013

    … class with disparate subcellular distributions: Prx1, Prx2 (both in the cytoplasm), Prx3 (mitochondria) and Prx4 (endoplasmic reticulum). They possess an evolutionary adaptation within the C-terminus that allows these `sensitive' Prxs to be susceptible to hyperoxidation. Under normal conditions …

    wfu Repository record

  19. Microbial Diversity in the Human Mouth: Dominant Genera and their Interactions.

    Fergusson, Stacey VictoriaUniversity of York2010

    … published, particularly in relation to the prx gene (encoding the peroxidase peroxiredoxin), which lead to the proposal of multiple pathways of stress response existing in N. meningitidis. It was observed that N. meningitidis survival was increased in the absence of the bcp gene (encoding …

    whiterose Repository record

  20. Applications of Engineered Proteins in Redox Biology and Biomarker Detection Assay Development

    Hao, YiningMassachusetts Institute of Technology2022

    … apoptosis initiates before the collapse of Prx/Trx/TR antioxidant network. Then, a genetically encoded FRET sensor was used to design a high-throughput screening assay that identified three small-molecule drugs from over 600 compounds that can mediate toxicity through H₂O₂. This thesis also …

    mit Repository record

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