Global ETD Search
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Showing 1 to 20 of 137 for “"MMPs"”.
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Modellierung von Enzym-Inhibitor-Komplexen mit Schwerpunkt auf den Matrix-Metalloproteasen (MMPs)
… der Inhibierung von Matrix-Metalloproteasen (MMPs), welche mit zahlreichen pathologischen Prozessen assoziiert werden, erhofft. Als Enzymanalogon wurde hauptsächlich das bekannte Tp(Ph,Me)ZnOH (1) eingesetzt. Im Mittelpunkt der Untersuchungen stand das Koordinationsverhalten der …
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Visualizing the Spatial Localization of Active Matrix Metalloproteinases (MMPs) using MALDI Imaging MS
… chemokines, and matrix metalloproteinases (MMPs). The nature of the FBR requires the spatial and temporal regulation of these mediators. MMPs are an extremely large and diverse group of enzymes that play key roles in regulating the FBR. Precise spatiotemporal regulation of MMPs defines their …
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Metaloproteasas (MMPs) en carcinoma de próstata y tejido prostático normal: expresión diferencial de MMPs y sus inhibidores en tejido con carcinoma prostático y lesiones atípicas prostáticas procedente de piezas de prostatectomía y de biopsia prostática
… con tumores de alto riesgo. Las metaloproteasas (MMPs) en los últimos años han planteado un importante interés en la investigación del cáncer debido al papel que tienen en la degradación de la membrana basal y de la matriz extracelular, facilitando la invasión tumoral y las metástasis. El objetivo …
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Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
Neutrophil gelatinase-associated lipocalin (NGAL), also called lipocalin-2, is a secreted protein belonging to the lipocalin family proteins and actively participates into the proliferation, differentiation, and development of human tissues, including tumours. It positively modulates the activity …
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The Gelatinases and Autoimmune Disease
<p>Matrix metalloproteases (MMPs) are critical to an array of homeostatic processes but have also been implicated in many pathological states. The roles they play in innate immunity, regulation of physical barriers such as the blood brain barrier, and the healing process are the same ones that …
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DATA-DRIVEN MODELING AND CONTROL FOR TIME-VARYING MULTISTAGE MANUFACTURING PROCESSES
… time-varying Multistage Manufacturing Processes (MMPs). We first investigate the impact of modeling accuracy on the residual controls which are acknowledged as the main techniques for process monitoring of MMPs. The results confirm the importance of process modeling in the quality assurance …
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Proteomic Profiling of Pro and Active Matrix Metalloproteinases using Tandem Mass Spectrometry. Optimization of Affinity Chromatography and nHPLC-MALDI-MS/MS for Proteomic discrimination of Matrix Metalloproteinases in pre-clinical Cancer Model.
Matrix metalloproteinases (MMPs) network with other biological molecules to maintain the extracellular matrix (ECM) in normal physiology and perform different roles. Understanding and assigning specific role to each of 24 members of these endoproteinases is impeded because of lack of specific and …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… and invasion. The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules, and to perform key functions in tumor progression, and in other diseases. In this …
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Regulation of Matrix Metalloproteinases and Their Inhibitors by DNA Methylation in Human Gestational Tissues
… therapeutic avenues. Matrix metalloproteinases (MMPs) and specific endogenous tissue inhibitors of metalloproteinases (TIMPs) are key mediators of fetal membrane rupture during physiological and pathological labour. Membrane type MMPs (MT-MMPs) activate secreted MMPs in addition to degrading the …
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Transcriptional Regulation of Matrix MetalloProteinase-3 in Rat Brain Astrocytes.
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matix (ECM) components during normal and pathogenic condition. Documented expression of MMPs contributes to tissue remodeling, atherosclerosis, and inflammatory diseases. MMPs are tight regulated by …
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Characterisation and modulation of the gelatinase system of human Bruch's membrane
… enzymes called the matrix metalloproteinases (MMPs). Underlying mechanisms leading to diminished MMP activity in ageing Bruch’s remain unknown but functional changes of diminished transport are well documented. Ageing remains the biggest risk factor in AMD with nearly 30% of all individuals …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
… also investigated if matrix metalloproteinases (MMPs), one of HIF-1 downstream factors, are involved in the process of neonatal HI brain injury. We hypothesized that broad-spectrum MMPs inhibition confers neuroprotection by reducing tight junction proteins (TJPs) degradation and preserve BBB …
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The role of matrix metalloproteinases and their inhibitors in irinotecan-induced oral mucositis: an animal model.
… enzymes called matrix metalloproteinases (MMPs) have been recently postulated to play a part in mediating the damaging process seen in oral mucositis. It is well established that MMPs and their naturally existing inhibitors (tissue inhibitors of metalloproteinases; TIMPs) maintain a …
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Tissue inhibitor of metalloproteinase-1 contributes to ovulatory dysfunction in a rat model of endometriosis
… in endometriosis. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are involved in endometriosis, but both are crucial for ovulation. Endometriotic lesions produce TIMP1, upsetting the balance of MMPs and TIMPs which can affect the ovaries and other organs of the reproductive …
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Modulating metalloproteinase activity with protein nanofibrils
Matrix metalloproteinases (MMPs) belong to a family of over 20 structurally related zinc-dependent proteases. They play a crucial role in every stage of wound healing by regulating the balance between tissue synthesis and destruction. However, excessive proteolytic activity, especially of MMP9, …
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Effect of Maternal Hypoxia on the Cerebral and Cardiac Tissue Remodeling
… that fetal hypoxia causes reprogramming of MMPs and TIMPs expression patterns and activities leading to aberrant brain and heart development in the fetuses and neonates. In the first part of project, we tested the hypothesis that maternal hypoxia increases the activity of MMPs and decreases …
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Qualitative and Quantitative Technical Criteria for Determining the Minimum Miscibility Pressures from Four Experimental Methods
… to determine the minimum miscibility pressures (MMPs) of different light crude oilCO2 systems from four experimental methods, i.e., the slim-tube tests, coreflood tests, rising-bubble apparatus (RBA), and vanishing interfacial tension (VIT) technique. First, five slim-tube tests with the live …
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Cervical Remodeling/ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells
… characterized by increased metalloproteinases (MMPs) release and increased collagen degradation. However, different sources of MMPs were identified. Macrophages are the source of MMPs in PTD while cervical fibroblasts and columnar epithelial cells synthesize MMPs at term delivery. A dramatic …
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Glomerulosclerosis in the Col1a2-deficient mouse model : homotrimer pathogenesis and MMP expression
… expression of type I collagen and MMPs -2, -3, and -9 in wildtype, heterozygous and Col1a2-deficient glomeruli to determine whether the pathogenic collagen is homotrimeric in nature, and whether alterations in MMP expression play a role in disease progression. Analysis of whole …
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The Role of Extracellular Matrix and Matrix-Degrading Proteases in Neonatal Hypoxic-Ischemic Injury
… repeats) and matrix metalloproteinases (MMPs) exert effects on cell viability and may be associated with either protective or destructive processes after H-I. Both ADAMTSs (Cross et al. 2006; Tian et al. 2007) and MMPs (del Zoppo et al. 2007; Gu et al. 2005; Rosenberg et al. 2001) have …
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