Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 178 for “"Laboratory and Basic Science Research"”.
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Significance of Increased Tissue Transglutaminase In Hormone Refractory Prostate Cancer
… but also to other therapeutic modalities and hence become lethal. Currently, there is no effective treatment available for managing this cancer. These observations underscore the urgency to investigate mechanism(s) that contribute to the progression of hormone-responsive to …
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Identify Causes of Unacceptable Turnaround Time in Sample Recalls and Develop Corrective Actions to Improve Patient Service in the Clinical Laboratory
… project were to identify the causes of cancelled laboratory tests attributed to the preanalytical phase of testing, determine the most frequent, actionable cause, and work collaboratively to create a standard workflow to improve the quality of testing while concurrently saving wasted money and …
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Mutations in PARKIN (pdr-1) Results in Increased Reproductive Fitness in C. elegans
… that includes contributions from both genetic and environmental factors, with aging itself being the largest risk factor. These combined susceptibility factors are believed to accumulatively contribute to initiation and progression of Parkinson’s disease. Although most cases of PD are …
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Consequences of Endogenous Mitochondrial Oxidative Stress in the Heart
… copy number for mtDNA in singlecardiomyocytes and develop a methodology for sequencing mtDNA from single cells compared to normal controls. In this study, the constitutive Sod2 knockout mouse model was used. All mice were treated daily with the SOD2 mimetic, Euk-189. For the first time, …
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Effects of Heregulin on Muscle: A Biochemical and Histological Analysis
… junction (NMJ) gene expression in vitro and improve skeletal muscle function in dystrophic mice. However, it is unclear if the HRG effects were due to proliferation, cell survival, differentiation, or stimulation of NMJ formation to improve excitation-contractile coupling. To identify a …
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Coloration, Camouflage, and Sexual Dichromatism in the Northern Pacific Rattlesnake (Crotalus oreganus)
… snakes, natural selection has shaped coloration and patterning to match local habitats, and for males to show greater warning coloration than females due to a less sedentary lifestyle. The Northern Pacific Rattlesnake (<em>Crotalus oreganus) </em>is likely the most abundant ambush predator in …
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Impact of Exercise on Brain Responses to Visual Food Cues: An fMRI Study
… functional magnetic resonance imaging (fMRI) and an appetite questionnaire, we investigated the effects of a single bout of aerobic exercise on brain responses to visual food cues and subjective appetite responses. After an overnight fast, 30 (17M, 13W), healthy, habitually active subjects …
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Targeting Akt/Mtor Signaling Pathways During Murine Skin Tumor Promotion and The Impact of Dietary Energy Balance Manipulation
… carcinogenesis across a broad range of species and tumor types. Previous data has demonstrated differential signaling through Akt and mTOR via the IGF-1R and other growth factor receptors across the diet-induced obesity (DIO)/CR spectrum. Furthermore, mTORC1 is known to be regulated directly via …
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Understanding and Targeting The Immunosuppressive Tumor Microenvironment
… inhibitors (ICIs), such as anti-PD1/PD-L1 and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence indicates …
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Double-Strand Break Repair Pathways In Dna Structure-Induced Genetic Instability
… genetic instability in the form of DNA double-strand breaks (DSBs) (1, 2). Our laboratory found that the stability of these non-B DNA structures was different in mammals versus Escherichia coli (E.coli) bacteria (1, 2). One explanation for the difference between these species may be a result of …
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Bacteriuria as a Precursor of Intracatheter Encrustation
… urinary catheters necessitates catheter change, and 3) estimate potential criteria for a routine time for catheter changes.</p> <p>Forty-five catheters were examined after their removal from patients. Flow rates were determined on 33 of the catheters, and all fell within the normal range except …
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Characterization of Tcl1-Tg:P53-/- Mice That Resemble Human Chronic Lymphocytic Leukemia With 17P-Deletion
… most common adult leukemia in the United Statesand Europe. CLL patients with deletion of chromosome 17p, where the tumor suppressor p53 gene is located, often develop a more aggressive disease with poor clinical outcomes. However, the underlying mechanism remains unclear. In order to understand …
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Qualify Microplate Reader’s Specification and Establish the Acceptance Criteria for Modified PicoGreen Kit in Measuring cell-free DNA Concentration in Clinical Laboratory
… DNA (cfDNA) is an emerging biomarker that researchers are utilizing to detect diseases in patients, allowing physicians to accurately diagnose and treat patients at the individual level. A few applications that utilize cfDNA to detect diseases in IVD (in-vitro diagnostics) are non-invasive …
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MicroRNA Expression Signature of Retinal Pigmented Epithelial Cells Associated with the Phenotype of Age-Related Macular Degeneration
… factors such as glutathione-S-transferase-1 and catalase as well as increased lipid peroxidation, all of which resulting in the age-related increase in autofluorescent lipofuscin between the retina and the choroid. This prevents the proper deliverance of nutrients to the foundational layer of …
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Dual mTOR/HDAC Inhibition: Preclinical Development of a Novel Breast Cancer Therapy
… (human epidermal growth factor receptor-2) and/or estrogen receptor (ER) are overexpressed in ~80% of human breast cancers. Although modern therapeutics (e.g. Trastuzumab, Tamoxifen) target the HER2 and ER receptors, clinical resistance often develops due to activation of downstream …
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Effects of Increasing Cycling Cadence on Post-Cycling Gait Velocity: An Experimental Study
<p>Previous research has shown that increasing cycling cadence, rather than the workrate, can result in improved post-cycling gait velocity. However, the specific threshold of cycling cadence required to bring about clinically meaningful changes in gait velocity remains unknown. To address this …
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The Effect of Infection with Polyoma Virus on the Protein, RNA, and DNA of Mouse Embryo Cell Cultures
… cell monolayers infected with polyoma virus and uninfected control mouse embryo cells were maintained in Eagle’s Minimum Essential Medium for periods of time ranging from 0 to 168 hours. The cell layers were removed from the glass by trypsinization. Samples of the cells were counted in a …
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Effects of Food Consumption on Cell Proliferation in the Brain of Python regius
<p>Neurogenesis is an important and vastly under-explored area in reptiles. While the ability to generate new brain cells in the adult mammalian brain is limited, reptiles are able to regenerate large populations of neuronal cells. Pythons exhibit a characteristic specific dynamic action (SDA) …
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Caffeine Supplementation and Moderate Intensity Exercise Modulates the Cytotoxic Lymphocyte Subset (CD+8) in NaIve and Tolerant Individuals
… of caffeine supplementation on caffeine tolerant and caffeine naïve individual’s lymphocyte counts, apoptosis and migration levels. In addition, effects of exercise on post-caffeine ingestion lymphocyte counts, apoptosis and migration levels were determined. It was hypothesized that caffeine would …
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