Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"FGF-2"”.
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ANAGRELIDE E FATTORE DI CRESCITA FIBROBLASTICO-2 (FGF-2) NELLA TROMBOCITEMIA ESSENZIALE
anagrelide and fibroblast growth factor-2 levels in essential thrombocythemia, anagrelide and fibroblast growth factor-2 levels in patientswith essential thrombocythemia, abnormal production of interleukin (IL)-6 in essential thrombocythemia, janus kinase V617F mutation and inflammatory …
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Role of p53 and its isoforms in the expression of FGF-2 and tumoral neovascularization
… and tumor progression. I also focused my work on FGF-2 regulation by p53. In a first part, full length p53 (p53) and/or D133p53 isoforms were selectively knocked-down with siRNAs in human glioblastoma cells U87. Conditioned medium produced by tumour cells knocked- down for D133p53 inhibited …
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Therapeutische Angiogenese bei chronischer Myokardischämie - Applikation von FGF-2 mittels selektiver druckregulierter Retroinfusion im tierexperimentellen Modell am Schwein
… Retroinfusion des vaskulären Wachstumsfaktors FGF-2 in die Koronarvene auf das Kollateralwachstum (Arteriogenese), das Kapillarwachstum (Angiogenese), den myokardialen Blutfluss und die kontraktile Myokardfunktion bei chronischer, experimenteller Myokardischämie (Schwein) untersucht, und mit …
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The OP27 cell line as a model system to study the effects of FGF-2 in olfactory neuronal development
… test the effects of fibroblast growth factor-2 (FGF-2) in directing olfactory neurogenesis. The OP27 cells proliferate under the control of the retrovirus at the permissive temperature (33°C). When shifted to the non-permissive temperature (39°C) the SV40 large T antigen is inactivated and the …
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Preparation of Heparin Surface for Quantification of Fibroblast Growth Factor-2 (FGF-2) Binding Using Surface Plasmon Resonance (SPR)
… the interactions of fibroblast growth factor-2 (FGF-2) with the surface bound heparin. Kinetic rate constants of association and disassociation were calculated. The association data of FGF-2 with heparin was fit to a single compartment, well-mixed model as the data did not exhibit mass transfer …
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Understanding and Targeting the FGF-2/S6K2 Signal Pathway in Small Cell Lung Cancer Towards the Development of Novel Anti-Cancer Treatments.
… is initiated by Fibroblast Growth Factor 2 (FGF-2) binding its cognate receptor, Fibroblast Growth Factor Receptor 1 (FGFR-1). Downstream of receptor activation a signal complex forms consisting of three kinases – B-Raf, Protein Kinase C epsilon (PKCε) and Ribosomal S6 Kinase Beta II (S6K2) – …
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In vitro comparison of equine tendon- and bone marrow-derived cells expanded with FGF-2 prior to culturing with tendon matrix and IGF-I
… the effects of fibroblast growth factor-2 (FGF-2) on monolayer expansion of equine tendon- and bone marrow-derived cells prior to culture with autogenous acellular tendon matrix and insulin-like growth factor-I (IGF-I). Progenitor cells were isolated from six young adult horses, expanded in …
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O reestabelecimento da saúde após terapia peri-implantar de suporte para tratamento da mucosite está associado à elevação dos níveis de FGF-2: ensaio clínico-laboratorial controlado não randomizado
… que o fator de crescimento de fibroblastos 2 (FGF-2) promove proliferação de células endoteliais e atividade mitogênica, estritamente relacionada à capacidade regenerativa. Portanto este estudo teve por objetivo analisar os níveis de FGF-2 no fluido crevicular peri-implantar em pacientes …
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Endothelial cells and basement membrane : a co-regulatory unit for fibroblast growth factor-2 in hyperglycemic stress
… and function of fibroblast growth factor-2 (FGF-2) through changes in interaction between endothelial cells and basement membrane. We discovered that basement membrane associated FGF-2 increased linearly with culture glucose concentration. Using novel assays, we demonstrated that FGF-2 …
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Monotherapie mit Wachstumsfaktoren am porcinen Modell chronischer Myokardischämie : eine Evaluation anhand der globalen Herzfunktion und der Koronarangiographie
… Tiere intramyokardiale Injektionen mit 0,5 mg FGF-2-Protein (n=6), 2 mg VEGF121-Plasmid-DNA (n=7) oder 2 mg FGF-2-Plasmid (n=7). Nach Ablauf von drei Monaten wurden erneut alle Parameter bestimmt und mit den Baseline-Werten verglichen. Die Ergebnisse wurden einer ischämischen Kontrollgruppe …
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Einfluß von Wachstumsfaktoren und Wachstumsfaktorkombinationen auf Angio- und Arteriogenese am ischämischen Kaninchenmyokard : eine histologische Studie
… Ziel dieser Studie war, den Einfluss von VEGF-, FGF-2- sowie GM-CSF-Plasmid-DNA auf Angiogenese und Arteriogenese im ischämischen Kaninchenmyokard zu untersuchen. Desweiteren war von besonderem Interesse, ob und bei welcher DNA-Konzentration VEGF und FGF-2 synergistisch wirken könnten. Methoden: …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… factor (BDNF) and fibroblast growth factor (FGF-2) play major roles in regulating the survival and fate of progenitor cells in the adult mammalian brain. To determine the effect of BDNF or FGF-2 on neurogenesis in the injured adult brain, BDNF or FGF-2 were over-expressed in the …
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Equine Trophectoderm Cells and Their Role in Fetal-Maternal Recognition
… GF (EGF), Hepatocyte GF (HGF), Fibroblast GF-2 (FGF-2) and Insulin GF (IGF-1), suggesting these GF may be important targets during TE development in the early embryo. We hypothesized that treatment of iTr cells with these GF would induce changes in cell proliferation and expression of genes …
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Polysaccharide-based nanostructures for growth factor delivery and mesenchymal stem cell activation
… adsorption of basic fibroblast growth factor (FGF-2) was evaluated on heparin chitosan PEMs constructed on gold-coated glass, tissue culture polystyrene (TCPS), and titanium. In vitro testing of the FGF-2-loaded PEM constructed on TCPS and titanium was performed using ovine bone marrow-derived …
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Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
… to poor prognosis. Fibroblast growth factor 2 (FGF-2) signalling leads to cell death resistance by providing cancerous cells with survival signals that leads to therapy resistance. FGF-2 signalling results in the activation of hnRNP A1 boosting the translation of anti-apoptotic proteins BCL-XL …
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Evaluation wachstumsfaktor-vermittelter Myokardrevaskularisation am porcinen, chronisch ischämischen Myokard : eine histologische Studie
… Studie war, die Auswirkung einer Therapie mit FGF-2 und VEGF-A121 auf das Gefäßwachstum (Angio- und Arteriogenese) bei chronischer Myokardischämie im porcinen Modell zu untersuchen. <br>Methoden: Eine Woche nach Anlegen einer hochgradigen, proximalen RIVA-Stenose erfolgte eine intramyokardiale …
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Pharmacokinetics of local growth factor delivery in myocardial tissue
… factor (EGF) and basic fibroblast growth factor (FGF-2) were chosen as model growth factor because of their potency of inducing endothelial mitosis and angiogenesis invitro. The "effective" diffusivity and partition coefficient of radiolabeled EGF and FGF-2 in rat myocardium were obtained with a …
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Biomaterials-tissue interaction of an injectable collagen-genipin gel in a rodent hemi-resection model of spinal cord injury
… with and without Fibroblast growth factor-2 (FGF-2), a known astrocyte chemoattractant, incorporated within lipid microtubules (LMTs) to infiltration by primary astrocytes using an in vitro cellular outgrowth assay; 3) evaluation of select formulations of the gel, based on the in vitro …
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Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… that regulate Etv5 in germ cells and found FGF-2 and EGF up-regulate Etv5 mRNA and that FGF-2 mediated up-regulation occurs via the MAPK signaling pathway.
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