Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 52 for “"Epicardial"”.
-
BNC1 Regulates Human Epicardial Heterogeneity and Function
… epithelial-to-mesenchymal transition (EMT), epicardial cells migrate into myocardium, form coronary smooth muscle cells and cardiac fibroblasts, and instruct cardiomyocytes to proliferate and mature. Adult mammalian epicardium is quiescent, but reactivates post-injury with limited effect. …
-
Epicardial Wireless Pacemaker for Improved Left Ventricular Resynchronization (Conceptual Design)
… Another option for LV pacing is by using an epicardial lead. This option has proven to be safe and effective but requires major surgery. An epicardial lead is usually implanted by performing a thoracotomy. Many studies have been done to show the benefits of bi-ventricular pacing, therefore …
-
Usefulness of Echocardiographic Epicardial Adipose Tissue Assessment in Patients with Angina
… We studied the relationship of echocardiographic epicardial adipose tissue (EAT) to coronary artery disease (CAD) risk factors, including the metabolic syndrome (MS), and the extent of coronary atherosclerosis. BACKGROUND: The clinical significance of EAT for CAD, which has been observed during …
-
Cellular therapy for chronic heart failure: a key role for epicardial fibronectin
… tissues in vitro appeared to be underpinned by epicardial-secreted fibronectin. Thus, hESC-combination cell therapy holds clinical promise for ‘remuscularising’ chronically infarcted hearts.
-
Multiphysics computational modeling of implantable actuable devices for local epicardial therapy delivery
… exposure. Recently, our group has developed two epicardial (outer wall of the heart) delivery devices, called "Therepi" and "fibRobot", that are implantable, replenishable and actuatable. They have the potential to improve the efficiency of drug delivery by enabling the capability of giving …
-
Epicardial Adipose Tissue: Relationship with Cardiovascular Disease and the Effect of Therapeutic Interventions
… mediastinal visceral fat and, in particular, epicardial adipose tissue (EAT) may play a vital role in the pathophysiology of atherosclerosis and atherothrombosis. A predominant hypothesis in these studies was that EAT, because of its proximity to the coronary arteries, may contribute to the …
-
Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… lacking TGFβR3 exhibit inhibited invasion of epicardially derived cells (EPDCs) into the myocardium. This delay of cell invasion of EPDCs and formation of coronary vessels is lethal at E 14.5. Relative to Tgfbr3+/+ cells, epicardial cells lacking TGFβR3 are hypo-proliferative, deficient in …
-
Development and Analysis of a Minimally Invasive Post-Infarction Epicardial Patch Delivery Device
… of function. The Roche lab has developed an epicardial patch that can mechanically reinforce the heart back to prevent it from progressing into heart failure after a heart attack , but current implantation methods are too invasive. In this study, researchers designed and developed a delivery …
-
The Derivation of the Myocardial, Epicardial and Endocardial Lineages from Human Pluripotent Stem Cells
… of hPSC-derived mesoderm towards the epicardial and endocardial lineages. Access to these cell types will enable investigations on their role in human cardiovascular development, application for cardiac regenerative medicine and modeling of cardiovascular disease.
-
Measurement of Radiofrequency Induced Heating in Patients with Retained Post-Surgical Epicardial Leads During MRI
… electronic devices in the presence of epicardial leads were classified as contraindications in MRI. Much of the concerns were due to the possibility for the lead to interact with the radiofrequency (RF) field produced in the MRI scanner, causing a significant amount of heating in the …
-
Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
… pathogenesis. These cells form when a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and migrates into the myocardium. The pathways and mechanisms regulating epicardial derived cell (EPDC) development remain largely unknown. Using mice with epicardial specific …
-
Multiple Electrode Recording of Cardiac Activation.
… used to record the electrical activation of the epicardial surface of the heart during open heart surgery. It consists of flexible circuit materials and represents and improved version of a multiple electrode array already in use for the purpose of recording the activity of multiple epicardial …
-
Association of Aortic Vascular Stiffness with Epicardial and Pericardial Adipose Tissues on 64-Multidetector Computed Tomography : In Relation with Coronary Atherosclerosis
… the relation of vascular stiffness with epicardial (EAT) and pericardial (PAT) adipose tissues, as well as the presence and severity of CAC. METHODS: One hundred and eleven consecutive subjects, mean age 59±11 years, 78% male, underwent 64-multidetector row cardiac computed tomography …
-
A Comprehensive Evaluation of Cardiac Electro-Anatomic Mapping Using Body Surface Potentials
… determined 3D locations on the body and epicardial surface of the ventricles during sinus rhythm, ventricular pacing and VT. Concurrent electrical activity from the LV endocardium was reconstructed using a multi-electrode balloon catheter. Finally, torso anatomies were acquired …
-
Defining the Developmental Signals of the Cardiac Fibroblast
… epithelial to mesenchymal transition (EMT) of epicardial cells. The epicardium (outer surface of the heart) functions as a pool of progenitor cells for the coronary vasculature and interstitial connective tissue during embryonic development. Although several signaling pathways have been …
-
Individual and combined effects of exercise training and dietary fat on myocardial triglycerides in obese mice
… is primarily due to its inflammatory nature. Epicardial adipose tissue is a type of visceral fat located on the exterior of the heart. Recent evidence suggests an association between atherosclerosis, epicardial fat, and hepatic triglyceride deposition. PURPOSE -The purpose of this study was to …
-
Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… discovery of new targeted treatment strategies. Epicardial-to-mesenchymal transition (EMT) occurs post-MI as a mechanism to support neovascularization and cardiac healing. However, the endogenous EMT is not enough to support sufficient repair. The transcription factor Wilms’ tumor 1 (Wt1) and the …
-
A multi-channel system for use in cardiac electrophysiologic studies
… A typical configuration would acquire twenty epicardial, two references (one each from atrium and ventricle), one roving electrode and two surface lead signals. The epicardial signals are obtained from a custom-built electrode belt which is placed around the heart over the atrioventricular …
-
Investigating the role of macrophages in larval zebrafish heart regeneration
… and recombinant protein interventions, I found epicardial Vegfaa to be required for cardiomyocyte proliferation and macrophages to be required for early epicardial expansion. Finally, I showed Vegfaa to increase endocardial notch signalling, which is known to drive cardiomyocyte proliferation, …
-
Microcirculatory and Myocardial Physiology in Ischaemic Left Ventricualr Dysfunction
… were assessed using a novel trans-coronary epicardial voltage mapping technique.<br/>RESULTS<br/>We demonstrated that the microcirculatory expansion wave in the infarct-related artery is predictive of both infarct size and regional ventricular recovery following revascularization, assessed …
Page 1 of 3