Multiphysics computational modeling of implantable actuable devices for local epicardial therapy delivery

Over the past few decades, heart disease remainis the leading cause of death globally. Local myocardial delivery of cardiac therapies is a potential method to improve the efficiency and expand the variety of cardiac therapies due to its capability of providing high local concentrations with minimal systemic exposure. Recently, our group has developed two epicardial (outer wall of the heart) delivery devices, called "Therepi" and "fibRobot", that are implantable, replenishable and actuatable. They have the potential to improve the efficiency of drug delivery by enabling the capability of giving multiple dose of therapies with only one implantation surgery and reducing the foreign body responses through mechanical oscillation. In this thesis, we used different computational models (structural, drug diffusion, and fluid-structure interaction) to characterize the therapeutic effect of these two devices on the heart.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Fan, Yiling,S.M.Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• Ellen Roche.

• Mechanical Engineering.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/122145

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/122145