Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"EpSCs"”.
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The Skin Remembers: Epigenetic Memories of Inflammation Past
… of this task are skin epithelial stem cells (EpSCs). EpSCs reside in the basal layer of the skin, survive long-term, and are capable of both self-renewing and differentiating into multiple skin lineages. To efficaciously maintain the barrier, EpSCs must be able to sense and respond to …
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Kurz- und Langzeitplastizität an einer hippokampalen Körnerzell-Korbzell-Synapse
… exzitatorische postsynaptische Ströme (EPSCs) in <br>Paarableitungen (unitäre EPSCs) zwischen Körnerzellen (GC) und <br>Korbzellen (BC) des Gyrus dentatus sowie EPSCs in der Konfiguration der <br>extrazellulären Stimulation von Moosfaserkollateralen (compound EPSCs) <br>gemessen. Die …
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Untersuchungen zum Zeitverlauf der Transmitterfreisetzung an einer glutamatergen Synapse
… der Zeitverlauf von postsynaptischen Strömen (EPSCs) an einer glutamatergen Synapse untersucht, an der die postsynaptischen Rezeptoren aufgrund ihres Schaltverhaltens gut als Detektoren für den Glutamatzeitverlauf im synaptischen Spalt geeignet erschienen. Wenn der Inhalt von einzelnen Vesikeln …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… number of readily releasable quanta and AMPA mEPSCs were unchanged in P14-17 calyx synapses of CaV1.3-/- deaf mice. However, synaptic strength was augmented because presynaptic action potentials were broader leading to increased quantal release, consistent with lower paired-pulse ratios and …
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Wirkung von Cannabinoiden auf die Neurotransmission im Corpus striatum und in der Substantia nigra pars reticulata
… postsynaptischen exzitatorischen Ströme (EPSCs) wurden mit der Patch-Clamp-Technik registriert. Im Corpus striatum hemmte der Cannabinoidrezeptor-Agonist WIN55212-2 konzentrationsabhängig die IPSCs, antagonisierbar durch den CB1-Rezeptor-spezifischen Antagonisten SR141716A: dies beweist …
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On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
… the PF segment. PPF and fluctuation analysis of EPSCs in rat PCs confirmed that the release sites of AA synapses have a greater probability of transmitter release than PF synapses. Furthermore, AA release sites have greater mean quantal amplitude than PF synapses, which is not due to a different …
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Neurologin Function in Excitatory and Inhibitory Synapses
… change evoked IPSCs, but Bai1 decreased evoked EPSCs and increased the burst duration in the spontaneous responses, possibly because of some secondary responses. Therefore, we found NL-NRX though NL extracellular region is important for NL2 function in synaptic transmission, and BAIs may be …
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Expression and function of PSD-93 isoforms in hippocampal synapses
… ergaben, dass nur PSD-93delta und epsilon AMPAR EPSCs um 50-100% erhöhen und somit einen ähnlichen Phenotyp wie die alpha-Isoformen von PSD-95 und SAP97 haben. Obwohl das N-terminale alpha-Exon von PSD-93 sich prinzipiell wie ein klassisches alpha-Exon verhält, kann es die alpha-Funktion nicht …
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
… ifenprodil and DQP-1105 on elicited NMDAR-EPSCs suggested a developmental shift from primarily GluN2B to GluN2B/D. Activity dependent regulation was assessed by high frequency burst stimulation of glutamatergic afferents: in comparison to controls, significant downregulation of NMDARs was …
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The Role of Amino Acids and the Threonine-SAM Pathway in the Development of Bovine Inner Cell Mass and Pluripotency
… known as embryonic pluripotent stem cells (ePSCs) or embryonic stem cells (ESCs) or via reprogramming of somatic cells to their pluripotent state, known as induced pluripotent stem cells (iPSCs). PSCs are excellent tools for gene editing and accelerated breeding in livestock animals. So far, …
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Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations
… LTP-inducing paradigm. Faster NMDAR-mediated EPSCs deactivation kinetics were detected in neurons with Shank3 down-regulation, indicating a possible change to GluN2A-containing NMDARs. This may in part contribute to the deficit in NMDARdependent LTP observed in neurons with loss of Shank3 by …
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Glutamatrezeptoren und Ca2+-Homöostase in Hirnstamm-Motoneuronen der Maus
Glutamat stellt den wichtigsten Neurotransmitter im Säugerhirn dar. Bei einigen neuronalen Erkrankungen (Amyotrophe Lateralsklerose, Epilepsie, Chorea Huntington) gelten Glutamat-aktivierte Ionenströme allerdings auch als Hauptauslöser für degenerative Erscheinungen. Eine besondere Bedeutung nimmt …