Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"Endothelin-1"”.
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P27 Expression in Endothelin-1 Stimulated Mitogenesis
… been shown in our lab to synthesize and secrete endothelin-1 (ET-1). The endothelin-1 binds ETA receptors, this elevates intracellular calcium, stimulate DNA replication and cell division. This investigation explores ET-l's role as a mitogenic factor in corneal endothelial cells and addresses …
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The electrophysiological effects of Endothelin-1 in human atrial myocytes
… (AF) and elevated levels of catecholamines and endothelin-1 (ET-1), each of which affects the atrial L-type calcium current (ICaL) and consequently action potentials. Hypotheses: ET-1 modulates the effects of isoproterenol (ISO) on ICaL and action potentials in human atrial myocytes. Methods: …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
… between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and determine the role of leptin and adiponectin. The adipose tissue conditioned medium (ACM) inhibited the ET-1-induced hypertrophy in a concentration-dependent manner and this anti-hypertrophic …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… as Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1), which rises and falls with HIF levels. The absence of chronic elevation of these ligands prompted the question of how long-term effects of hypoxia is sustained. Results suggest that in addition to stimulating transient rises in …
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Endothelin-1 Induced Phosphorylation of ERK1/2 in Bovine Corneal Endothelial Cells
… purpose of this study was to determine whether Endothelin-1 (ET-1) induced cellular responses in bovine corneal endothelial cells (BCECs) involves MAPK pathway by phosphorylating ERK1/2 protein kinase and to find out the phosphorylation patterns of ERK1/2 in confluent and sub-confluent cells. …
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Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… premature infant, and leads to the production of endothelin-1. Our study aims to test the hypothesis that perinatal hypoxia exposure induces a premature terminal differentiation of cardiomyocytes, focusing on the role of endothelin-1 and the underlying epigenetic and molecular mechanisms. We …
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Endothelin-1 is over-expressed in Amyotrophic Lateral Sclerosis and induces Motor Neuron cell death
… contribute to degeneration of MNs. We focused on endothelin-1 (ET-1), a peptide which is strongly up-regulated in reactive astrocytes under different pathological conditions. We show that ET-1 is abundantly expressed by reactive astrocytes in the spinal cord of the G93A mouse model and sporadic …
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… stretch and osmotic swelling. Because endothelin-1 (ET-1) is a potential downstream mediator of AngII and ETA receptor blockade abrogates AngII-induced ROS generation, we studied how ET-1 signaling regulates ICl,swell and the relationship between AngII and ET-1 signaling. Under …
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Proatherosklerotische Wechselwirkung von oxidativem Stress, Low-Density-Lipoprotein, Angiotensin II und Endothelin-1 in humanen Endothelzellen
… Lipoproteinen und den blutdruckregulierenden Endothelin- und Renin-Angiotensin-Systemen untersucht. Weiterführende Analysen erfolgten an Rezeptoren für die Aufnahme von nLDL und oxLDL. Abschließend wurden Signalwege untersucht, die durch nLDL und oxLDL aktiviert werden. Tierexperimentielle …
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The Effect of Endothelin-1 on the expression of CDK Inhibitors p21 & p27 in Bovine Corneal Endothelial Cells
… inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal endothelial cells). BCECs were isolated from bovine corneas and cultured in DMEM supplemented with 10% …
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Einfluss von Angiotensin II und Endothelin-1 auf die Kontraktilität isolierter Kardiomyozyten aus gesundem und terminal insuffizientem Myokard
… untersuchte den Einflussvon Angiotensin II und Endothelin-1 auf die Kontraktilität isolierter Myozyten aus Vorhof- sowie gesundem und terminal insuffizientem Ventrikelmyokard. Darüber hinaus sollte die intrazelluläre Signaltransduktion aufgeklärt werden. <br>Um die Signaltransduktion des …
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The relationship between circulating biomarkers of nitric oxide and endothelin-1 and hemodynamic function in obstructive sleep apnea
… tone, with a predominance of the vasoconstrictor endothelin-1 (ET-1) and removal of the vasodilator nitric oxide (NO). Means to reduce the effects of ET-1 and increase synthesis of NO may have beneficial effects on the cardiovascular co-morbidity commonly associated with OSA. OBJECTIVES: The major …
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Einfluss der beiden endogenen Peptide Angiotensin II und Endothelin-1 auf die Kontraktilität isolierter Kardiomyozyten von menschlichem Vorhof- und Ventrikelmyokard
… erklären. Neue Therapieversuche mit Endothelin-Rezeptorenblockern sollen nachteilige Effekte dieses Peptids auf das insuffiziente Herz verringern. Die Wirkung von Angiotensin II und Endothelin 1 auf das menschliche Herz ist noch weitgehend ungeklärt. Die vorliegende Arbeit untersucht …
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A comprehensive study of the impact of contrast medium on endothelial cells in vitro: validating the protective effects of n-acetylcysteine and assessing the importance of endothelin-1 and glutathione on contrast-induced nephropathy in patients with chronic kidney disease
… explored, the powerful vasoconstrictor, endothelin-1 (ET-1), was the only marker to significantly increase following exposure to CM, but only when GSH was depleted. These results demonstrated, for the first time, a significant increase in ET-1 levels in a GSH depleted EA.hy926 cell model, …
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Studies of the mammalian ovarian endothelin system
In porcine ovaries, endothelin-1 (ET-1) may have an autocrine/paracrine role in follicular development. Endothelin-converting enzyme-1 (ECE-1) converts big endothelin-1 to ET-1. In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
… the white matter stroke model. We have developed endothelin-1 induced white matter stroke model where a localized demyelinative lesion is created in the internal capsule in rats. The ischemic demyelinative lesions were visible animals in 9.4T MR images, allowing us to determine the therapeutic …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… correlates with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also …
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Functional recovery in young adult and aged rats following delayed, intramuscular treatment with neurotrophin-3 after focal stroke injury.
… efficient treatment. This thesis utilises an endothelin-1 model of focal ischemic stroke to evaluate functional recovery in adult and aged rats following treatment with neurotrophin-3 (NTS). Endothelin-1 produces a reduction in local blood flow to levels that produce ischemic injury when …
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