Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 56 for “"DRUG INTERACTION"”.
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Evaluation of drug-drug interaction in the EHR data
Drug–drug interactions (DDIs) caused by co-prescriptions can alter the effectiveness of treatment or occurrence of adverse drug events (ADEs). Also, it in itself could be life-threatening to patients. An electronic alert for DDI is one of the most successful components of electronic medical record …
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DLRNA-BERTa: A transformer approach for RNA-drug interaction prediction
… efficient approach to accelerate RNA-targeted drug discovery. In this thesis, we propose a RoBERTa-based model (DLRNA-BERTa), a dual language model architecture designed to predict the interactions between small molecules and RNA targets using only textual information across six distinct RNA …
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CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction
… metabolite of sarpogrelate) on CYP isoforms or drug–drug interactions. Using a cocktail assay, the effects of sarpogrelate and M-1 on nine CYP isoforms were measured by specific marker reactions in human liver microsomes. Nine healthy male subjects genotyped for CYP2D6*1/*1 or *1/*2 were …
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Nutrient Drug Interaction Probability Scale (NDIPS): A Creation and Validation Process
Background:Drug-nutrient interactions (DNIs) are interactions between drugs and nutrients that can result in clinically relevant physiological alterations. Despite their potential impact, the importance of DNIs is heavily undervalued and overlooked. Evaluation of drug safety mainly focuses on …
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Phytochemical Investigation and Drug Interaction Potential of <em>Cyanotis vaga</em>
… there are no reports about its effect on the drug metabolizing enzyme Cytochromes P450 to predict its interaction with concomitantly used medications. In this study, eight ecdysteroids were isolated from <em>C. vaga</em>, including two previously reported from <em>C. vaga</em>. The additional …
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Artesunate and amodiaquine : tolerability and drug interaction study in healthy normal volunteers
Includes bibliographical references.
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Translational high-dimesional drug interaction discovery and validation using health record databases and pharmacokinetics models
Polypharmacy leads to increased risk of drug-drug interactions (DDI’s). In this dissertation, we create a database for quantifying fraction of metabolism (fm) of CYP450 isozymes for FDA approved drugs. A reproducible data collection protocol was developed to extract key information from publicly …
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A Bayesian Approach to Dose-Response Assessment and Drug-Drug Interaction Analysis: Application to In Vitro Studies
… reduction in toxicity and minimizing or delaying drug resistance. Dose-response assessment and drug-drug interaction analysis play an important part in the drug discovery process, however analysis are often poorly done. This dissertation is an effort to notably improve dose-response assessment and …
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Toxicology and herb-drug interaction of selected anti-hypertension plants used by lay persons in Northern KwaZulu-Natal (South Africa)
… as well as concurrently with conventional drugs to treat hypertension. Because of the lack of studies validating the safety of South African medicinal plants and the limited interactive studies done between medicinal plants and conventional drugs this study was undertaken. The study was …
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PharMeBINet: a general-Purpose approach for the integration of heterogeneous biomedical data Sources and its application to drug-drug interaction prediction
… quality are used for multiple tasks, like drug repurposing, or the prediction of drug-target interactions, drug-drug interactions, or side effects for polypharmacy.<br /><br /> This thesis analyzes and compares existing KGs regarding their adherence to defined essential features for KGs. A …
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Novel drug interaction for improving intracellular accumulation and efficacy of chemotherapeutics in retinoblastoma and mitochondrial localization of transporters in corneal epithelial cells
… permeability and chemoresistance due to major interaction with multidrug resistant (MDR) efflux proteins (MDR1 and MRP2) over-expressed on retinoblastoma tumor. Ocular cells have shown good tolerability against antimicrobial moxifloxacin (fourth generation fluoroquinolone) at higher dose level. …
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FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
… and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs (buspirone, caffeine, dextromethorphan and losartan) used to probe cytochrome P450 (CYP) activities, a significant decrease in …
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Avaliação do sinergismo entre os componentes da pasta ctz e o citronelol frente ao enterococcus faecalis
The objective of this study was to evaluate the drug interaction between components of CTZ paste (chloramphenicol, tetracycline, zinc oxide and eugenol) and citronellol phytochemical against Enterococcus faecalis (ATCC 29212). The checkerboard test was performed to verify the interaction between …
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Using Genetic Epidemiologic Methods to Explore the Influence of Gene-Environment Interactions on Colorectal Adenoma Recurrence
… Data were analyzed to test for gene-environment interactions between allelic variation in PPAR-γ (Pro12Ala, C1431T), body mass index (BMI) and waist circumference, and the biochemical biomarkers of metabolic syndrome. Simulated data were then used to determine if the sample size required to …
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
… Induction of CYPs contributes to adverse drug-drug interactions. Non-toxic, PXR-specific antagonists will be valuable in attenuating the adverse drug-drug interaction which is the cause of many treatment failures in clinic. However, few hPXR antagonists were reported particularly the …
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Safety Assessment and Chemical Fingerprint Analysis of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (<em>Aspalathus Linearis</em>) and Moringa (<em>Moringa Oleifera</em>)
… concisely. Specifically, the impact of herb-drug interaction on consumers and the quest for chemical markers for chemical fingerprinting development are provided. Rooibos tea (<em>Aspalathus linearis</em>) is a popular South African herbal tea enjoyed worldwide. Limited reports indicate the …
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Cytokine and Chemokine Profiles in a Rat Model of Hemorrhagic Shock after Immuno-Modulation by Androstenetriol
… injury, and how they are modulated during drug interaction, can facilitate novel treatment strategies for future trauma patients. We hypothesize that the pharmacological agent, Androstenetriol (AET), up regulates host immune response by modulating the continued expression of mediators, …
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Medication concepts, records, and lists in electronic medical record systems
… as duplication checking, allergy checking, and drug-drug interaction alerts. Clever modeling of medication records makes it easy to provide a history of any medication the patient is on and to generate the patient's medication list for any arbitrary point in time. Medication lists that …
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Implantação de práticas seguras para o uso de medicamentos no Hospital Napoleão Laureano : elaboração de um guia farmacoterapêutico para a utilização dos MPP
… MPP (MPP). The MPPs are defined as a group of drugs that have an increased risk of d amage to bring the wearer. The cancer patients makes use of various drugs, adjuvant therapy, in addition to used in cancer treatment and therefore the focus of your treatment ends up being the chemotherapy, and …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
… diseases, and often is further complicated by drug interaction and malabsorption issues when combining antiretroviral treatment and TB chemotherapy. The molecular basis for pathogen synergy that leads to an aggressive course of TB in those with HIV-1 infection, however, is poorly defined. This …
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