Phytochemical Investigation and Drug Interaction Potential of <em>Cyanotis vaga</em>

<em>Cyanotis. vaga</em> (Lour.) Schult, & Schult. f. (<em>C. vaga</em>) previously called <em>Tradescantia vaga</em> and <em>Cyanotis barbata</em>, is a perennial herb. It is native to Eastern Asia and Tropical Africa. It has been reported that its decoction reduces fever and enhances well-being. Recently, <em>C. vaga</em> has been used widely for its anabolic effects, due to its richness of ecdysteroids. Even though <em>C. vaga</em> is a commedicinal plant (dietary supplement), there are no reports about its effect on the drug metabolizing enzyme Cytochromes P450 to predict its interaction with concomitantly used medications. In this study, eight ecdysteroids were isolated from <em>C. vaga</em>, including two previously reported from <em>C. vaga</em>. The additional six ecdysteroids were reported for the first time from this plant. The extract and isolates were tested for their inhibitory effects on the CYP3A4 enzyme, which is a major CYP isoform involved in the metabolism of commonly-used clinical drugs.

Name thesis:degree_name

M.S. in Pharmaceutical Science

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Pharmaceutics and Drug Delivery

Year dc:date.available

2019

Author dc:creator

• Almarabi, Ibrahim

Contributors dc:contributor

• Ikhlas A. Khan
• Robert J. Doerksen
• Samir Ross

• Pharmacy and Pharmaceutical Sciences

Repository record dc:identifier

https://egrove.olemiss.edu/etd/1579

OAI identifier oai:identifier

oai:egrove.olemiss.edu:etd-2578